How does phosphatidylserine support brain health in aging
Dec 26, 2024
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Phosphatidylserine, also known as complex neuraminic acid. The English name is Phosphatidylserine, referred to as PS, which is extracted from the residue of natural soybean oil extraction. It is the phospholipid component of the membrane that wraps each of our brain cells, and it helps maintain their fluidity and permeability, so that proteins, enzymes, oxygen and glucose can effectively enter and exit each cell. On the other hand, phosphatidylcholine (PC) is the most abundant phospholipid in the brain and is present in the outer layer of brain cell membranes. PS accounts for about 15% of the total phospholipid pool in the brain and is part of the inner layer of the cell membrane. Of course, both are essential for maintaining optimal cognitive health. PS is involved in controlling membrane fluidity and regulating all activities that go on in that brain cell. When brain cell membranes are healthy, they are ductile, fluid and flexible. But as we age, phospholipids, including PS, begin to decline. Cell membranes begin to harden, and attention, concentration, memory, mood and learning begin to be affected.
Phosphatidylserine interacts with cellular proteins to regulate the activity of neural receptors, enzymes, ion channels and signaling molecules. It's also involved in building mitochondria, the energy centers of every brain cell, and even promotes the production of nerve growth factor (NGF).
Some research on the effects of PS on the brain
1. Jorissen BL et al. conducted a comprehensive evaluation of the safety performance of PS product treatment, taking 120 elderly ARCD and AAMI patients as the research subjects. The results showed that after 6 to 12 weeks of PS product treatment, the patients' various biochemical indicators, blood indicators and There is no significant difference between heart rate and standard safety indicators. This study proves that taking 200mg of PS products daily for nutritional supplementation can not only improve cognitive decline and memory damage caused by age, but also has no side effects.
2. Studies have shown that supplementing PS can increase the number of brain spines, enhance the fluidity of brain cell membranes, and promote glucose metabolism in brain cells, thereby achieving the effect of making brain cells more active. Currently, PS supplements are widely used in many countries to treat dementia caused by aging and memory loss in the elderly.
In a study published in "Marine Drugs", the neuroprotective effects of DHA-rich phosphatidylserine and EPA-rich phosphatidylserine on oxidative damage in primary hippocampal neurons were compared. The study found that DHA-PS and EPA-PS can It can significantly improve cell morphology, promote the recovery of neural network structure, and significantly alleviate oxidative stress-mediated mitochondrial dysfunction, providing a scientific basis for the use of DHA/EPA-rich phospholipids to treat neurodegenerative diseases.
What are the main effects of PS?
Neurotransmitter Regulation
Phosphatidylserine can promote the release of neurotransmitters, regulate the uptake of neurotransmitters, and affect the function of neurotransmitter receptors. It can increase the synthesis and release of acetylcholine and increase the level of acetylcholine in the brain. Acetylcholine is an important neurotransmitter that participates in various cognitive functions of the brain.
Neuroprotective Effect
Phosphatidylserine has an important protective effect in the nervous system, which can promote the survival and growth of neurons and reduce the apoptosis of nerve cells. It can play a neuroprotective role through multiple mechanisms such as reducing oxidative stress, regulating the release of neurotransmitters and promoting the metabolism of nerve cells.
Anti-Inflammatory Effect
Phosphatidylserine has anti-inflammatory effects and can inhibit inflammatory responses and the release of cytokines. It can regulate the activity of immune cells, inhibit the adhesion and migration of leukocytes, and reduce the synthesis and release of inflammatory mediators, thereby reducing inflammatory responses and tissue damage.
Anti-Aging Effect
Phosphatidylserine has anti-aging effects and can reduce cell aging and organ function decline. It can enhance the metabolic activity of cells, improve antioxidant capacity, reduce DNA damage and cell apoptosis, thereby delaying the aging process of cells and tissues.
Improve Memory And Cognitive Function
Phosphatidylserine is considered to be beneficial for improving memory and cognitive function. It can promote the connection and transmission of neurons and enhance learning and memory ability. Studies have shown that phosphatidylserine can improve aging-related cognitive dysfunction, such as Alzheimer's disease.
Emotional Regulation
Phosphatidylserine can also regulate emotional state and relieve negative emotions such as anxiety and depression. This is related to its promotion of the release of neurotransmitters such as dopamine, regulating the function of neurotransmitter receptors, and affecting the distribution of neurotransmitters in the brain.
What are the main application industries and fields?
Food additives
As food additives, they are used in functional foods and health products to improve cognitive function, improve attention and memory, and support brain health.
Health products
They are often used as nutrients to enhance memory, improve sleep, and protect cardiovascular and cerebrovascular systems, and are widely used in the health products market.
Medicine
They show good application prospects in the medical field, especially in improving nerve cell function and regulating nerve impulse conduction.
Dairy products and infant formula: They can be used as emulsifiers and stabilizers in the production of dairy products and infant formula, which are beneficial to the neurological development of infants and young children.
Dietary supplements: As dietary supplements, they are supplemented in the form of capsules, powders or liquids, claiming to improve cognitive function, relieve stress and anxiety, etc.
Cosmetics and personal care products: They are also used in the field of cosmetics and personal care products.
Functional foods: They have high growth potential in the field of functional foods, and can provide more consumption scenarios and experiences to meet the needs of consumers of different ages and preferences.
Medical foods: They are also used in the field of medical foods, especially when specific nutritional support is required.
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PS is suitable for people
Neuron cells begin to decline after the age of 40. Simply put, people over 40 can take PS. In terms of formula, it is necessary to consider the nutrition of neurons themselves and the dredging of neurons.
People between 40 and 60 years old whose brain emergency response is weakened can take PS in moderation. If this state has lasted for a period of time and has a tendency to worsen, it is recommended to consider increasing the amount of PS after consulting a doctor.
People over 60 years old or children can take PS in small amounts to strengthen their brains.
About JIUYUAN BIOTECH
Shaanxi Jiuyuan Biotechnology Co., Ltd. was established in 2012, focusing on the production of plant extracts, health food raw materials, fruit and vegetable powder, feed additives and other products. Our factory covers an area of more than 70,000 square meters and has production lines such as plant extraction and fine extraction workshops. The production process is strictly operated in accordance with GMP operating specifications. A high-quality R&D team and advanced scientific research equipment ensure the effectiveness and safety of the products. So far, the company has obtained many certifications including ISO9001 quality management system certification, ISO22000 food safety management system, HACCP certification, US FDA inspection certification, halal certification, kosher certification, USDA/EU Organic Certificates, etc., and enjoys a certain reputation in the field of plant extracts.
PS is one of our main products, and in terms of overall quality
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