Polygonum Cuspidatum Extract Powder

Polygonum Cuspidatum Extract Powder  is 3, 4', 5-trihydroxystilbene. When seed plants are exposed to fungal infection and UV radiation, they create a plant defensin to protect themselves. Knotweed and grapes are the main sources of natural resveratrol. Polygonum Cuspidatum Extract Resveratrol's antioxidant, anti-inflammatory, anti-cancer, and cardiovascular protective benefits are becoming recognised and used in human health.

At Jiuyuan Biotech, our extract is produced from cultivated P. cuspidatum root harvested from Shaanxi and Hubei provinces - regions with the soil alkalinity and seasonal temperature variation that favor high stilbene accumulation in the root tissue. Every batch is HPLC-standardized and ships with a full Certificate of Analysis.

The phytochemical profile of P. cuspidatum root extract is anchored by three structurally distinct compound classes, each with a different mechanism of action and a different set of commercial applications.

Stilbenes (Primary Commercial Fraction)

• Trans-Resveratrol (3,5,4'-trihydroxy-trans-stilbene) - The primary commercial marker and the most extensively researched polyphenol in the longevity science literature. Acts as a SIRT1 activator, a free radical scavenger, an NF-κB inhibitor, and a modulator of AMPK signaling. The trans isomer is the biologically active form; the cis isomer, produced by UV-induced isomerization, is substantially less active. HPLC isomer ratio verification is therefore a critical quality parameter - not a secondary concern.
• Polydatin (Piceid; Resveratrol-3-O-β-D-glucoside) - The glycosylated precursor to trans-resveratrol. More water-soluble and more stable than the aglycone form, making it technically easier to incorporate into aqueous formulations. Converted to free resveratrol by intestinal β-glucosidase activity in vivo. Increasingly studied as a standalone bioactive with distinct pharmacokinetic advantages over resveratrol aglycone, including faster gastrointestinal absorption in some models.
• Oxyresveratrol - A hydroxylated resveratrol analog present at lower concentrations; documented antioxidant and anti-melanogenic activity, with relevance to skin brightening applications in cosmetics.

Anthraquinones

• Emodin (1,3,8-trihydroxy-6-methylanthraquinone) - The dominant anthraquinone in P. cuspidatum root. Documented anti-inflammatory, antibacterial, antiviral, and hepatoprotective activities in preclinical research. Also exhibits laxative activity at higher doses - a pharmacological property that is relevant to both its traditional use and its regulatory classification in some jurisdictions. Emodin is available as a separate high-purity grade (≥ 90% HPLC) for formulators targeting its specific activity profile.
• Physcion - A methyl ether derivative of emodin; present at lower concentrations, contributes to the anthraquinone fraction.

Stilbene Oligomers & Other Polyphenols

• ε-Viniferin - A resveratrol dimer; present in root extracts at low concentrations; documented antifungal and antioxidant properties.
• Catechin, Epicatechin - Flavanol monomers present in the root extract; contribute to overall antioxidant capacity.
• Quercetin Glycosides - Minor flavonoid contributors to the polyphenol profile.

1. We strictly screen raw materials to ensure that the knotweed plant grows in the best environment, without pollution, to ensure the purity and high quality of the raw materials.
2. Use industry-leading extraction technology to ensure the extraction efficiency and purity of resveratrol while retaining its biological activity to the maximum extent.
3. Implement a strict quality control system, from raw materials to finished products; every link is strictly tested and monitored.
4. Provide customized services, adjust product specifications and formulas according to the specific needs of customers to meet the needs of different markets and customers.
5. Our products have obtained several international certifications and qualifications, which not only prove the high standards of our products but also provide a solid foundation for the expansion of the global market.

Polygonum Cuspidatum Root Extract for Skin

The antioxidant capabilities of resveratrol and rhamnolide include LDL cholesterol oxidation and lipid peroxidation.

Enhance memory and cognition

May enhance age-related cognitive decline, including attention management, memory, and processing speed.

Avoid heart and liver damage

By reducing fat peroxidation, it can reduce hepatic triglyceride and cholesterol deposition and boost aspartate and alanine aminotransferases.

Cardiovascular effects

It dilates blood arteries, inhibits platelet aggregation, improves microcirculation, protects the endothelium, and lowers blood pressure.

Low-lipid effect

Polygonum cuspidatum extract resveratrol and glycosides significantly decrease blood cholesterol and triglycerides.

Microbial antipathogenicity

It strongly inhibits Staphylococcus, Streptococcus, and viruses.

Medical field

It can be directly used in a variety of anti-inflammatory drugs, cardiovascular drugs, anti-cancer drugs, etc.

Polygonum cuspidatum supplement

Due to its antioxidant, anti-inflammatory, anti-tumor, and other biological activities, it has broad application prospects in the field of healthcare products.

Cosmetic industry

The antioxidant and anti-aging properties of this ingredient make it a popular ingredient in the cosmetics industry.

Food industry

Polygonum Cuspidatum Extract Resveratrol is also widely used in the food field as a natural antioxidant and plant secondary metabolite.

Application Category	Primary Mechanism	Typical Use Level	Format Compatibility
Longevity & Anti-Aging	SIRT1 activation, NAD⁺ pathway support, senolytic activity	100–500 mg/serving	Capsule, tablet, softgel
Cardiovascular Health	Endothelial protection, LDL oxidation inhibition, platelet aggregation modulation	100–250 mg/serving	Capsule, tablet
Metabolic & Blood Sugar Support	AMPK activation, insulin sensitization, lipid metabolism	150–500 mg/serving	Capsule, tablet
Cognitive & Neuroprotective	Antioxidant neuroprotection, neuroinflammation reduction, cerebral blood flow	100–250 mg/serving	Capsule, softgel
Sports & Recovery	Mitochondrial biogenesis (PGC-1α), oxidative stress reduction	150–300 mg/serving	Capsule, powder blend
Cosmetics & Skincare	Antioxidant, anti-aging, skin brightening (oxyresveratrol)	0.05–1.0% w/w	Serum, cream, ampoule
Immune Support	NF-κB modulation, antiviral (emodin fraction)	100–300 mg/serving	Capsule, tablet
Women's Health	Phytoestrogenic activity (weak), anti-inflammatory	100–250 mg/serving	Capsule, tablet

Market context: The global resveratrol market is driven by the convergence of longevity science, biohacking culture, and mainstream anti-aging supplement demand. The emergence of NAD⁺ precursor supplements (NMN, NR) has actually expanded the resveratrol market rather than displacing it - many longevity-focused consumers stack resveratrol with NMN or NR based on research suggesting synergistic SIRT1 pathway activation. For brands in the longevity space, P. cuspidatum extract remains the most cost-effective, analytically well-characterized source of trans-resveratrol available at commercial scale.   

Shaanxi Jiuyuan Biotechnology Co., Ltd. is a modern high-tech enterprise established in 2012, focusing on the research, development, production, and sales of plant extracts, health food ingredients, fruit and vegetable powders, food additives, and other products. The factory spans an area of over 70,000 square meters and features production lines, including plant extraction and fine extraction workshops. The production process is strictly operated following GMP operating specifications.

Production and operation licenses, cGMP, ISO9001 quality management system certification, ISO22000 food safety management system, HACCP certification, U.S. FDA inspection certification, halal certification, Kosher certification, etc. In the field of plant extracts, Jiuyuan complies with relevant standards and requirements throughout the production, development, and sales processes.

Choosing Between Extract Grades

Polygonum Cuspidatum Extract vs. Other Resveratrol Sources

The commercial reality is unambiguous: P. cuspidatum root is the only botanical source from which trans-resveratrol can be extracted and purified at commercial scale with consistent quality and competitive economics. Grape-derived resveratrol, while popular in consumer marketing narratives, is not commercially viable as a standardized ingredient source.

1. Modern high-tech enterprise: JIUYUAN BIOTECH was established in 2012. It is a modern high-tech enterprise integrating the research and development, production, and sales of plant extracts, health food raw materials, fruit and vegetable powders, feed additives, etc.
2. Professional R&D and production capabilities: The company has two production lines of plant extraction and refined extraction workshops, covering an area of more than 70,000 square meters. It focuses on product production and quality. The production of each link constitutes a set of refined, professional and systematic scientific processes. Quality management system.
3. Environmentally friendly extraction methods: JIUYUAN BIOTECH adopts environmentally friendly extraction methods, such as the green strategy of using deep eutectic solvents (DESs) to extract resveratrol. This method does not require the use of organic solvents, providing a simpler and more environmentally friendly method. alternative method.
4. Efficient extraction and conversion technology: The strategy developed by the company can successfully and efficiently convert polydatin in Polygonum cuspidatum into resveratrol. The optimized extraction conditions and reaction parameters can significantly increase the production of resveratrol.
5. Quality Control Analysis Center: JIUYUAN BIOTECH's quality control analysis center is equipped with advanced equipment such as ICP-MS, GC-MS, FTIR, HPLC, GC, UV, etc. to ensure product quality and stability. At the same time, it has established a strict quality assurance system to ensure The entire production process complies with cGMP and other standards.

6. Real-time supervision and control: The company follows HACCP and GMP management principles, and the experienced QA and QC team ensures that the best quality products are always provided to customers through real-time supervision and control.

We offer three standard packaging formats, each designed around a specific order volume and transit risk profile:

ByAir

100kg-1000kg, 5-7Days

Airport-to-airport service professional

clearance broker needed

BySea

Over300kg, Around 30 Days

Port-to-port service professional

clearance broker needed

Express

Under 100kg, 3-5Days

Door-to-door service easy to pick up the goods

Q1: Why is the trans/cis isomer ratio so important, and how do I verify it on a supplier's COA?

Trans-resveratrol and cis-resveratrol are geometric isomers with meaningfully different biological activity profiles. The trans form is the isomer studied in the vast majority of published research - it is the form that activates SIRT1, modulates AMPK, and inhibits NF-κB at physiologically relevant concentrations. The cis isomer, produced by UV-induced photoisomerization of the trans form, is substantially less active by most measures. On a supplier COA, look for two separate HPLC peaks reported: one for trans-resveratrol and one for cis-resveratrol, with the trans fraction confirmed at ≥ 98% of total resveratrol content for high-purity grades. A COA that reports only "resveratrol ≥ 98%" without specifying the isomer ratio is incomplete and should prompt a clarification request before purchase.

Q2: What is polydatin, and when should I choose it over trans-resveratrol aglycone?

Polydatin (piceid) is the 3-O-glucoside of resveratrol - essentially resveratrol with a glucose molecule attached at the 3-hydroxyl position. It is the predominant form of resveratrol found in planta in P. cuspidatum root, and is converted to free resveratrol by intestinal β-glucosidase enzymes in vivo. Its practical advantages over the aglycone form are: significantly higher water solubility (making it far easier to formulate into aqueous products such as beverages, effervescent tablets, and liquid supplements), and greater chemical stability under ambient storage conditions. The trade-off is that the conversion to free resveratrol in vivo is enzymatically mediated and may vary between individuals. For solid dosage forms (capsules, tablets) where solubility is not a constraint, trans-resveratrol aglycone is the more direct and better-researched choice. For aqueous formulations, polydatin is the technically superior option.

Q3: What does the research say about resveratrol and longevity / SIRT1 activation?

The SIRT1 activation hypothesis for resveratrol - first proposed by Howitz et al. in Nature (2003) and subsequently developed by David Sinclair's laboratory at Harvard - posits that resveratrol activates sirtuins, a family of NAD⁺-dependent deacetylases that regulate cellular stress responses, mitochondrial biogenesis, and aging-related gene expression. Subsequent research has been more nuanced: direct SIRT1 activation by resveratrol in vitro has been debated, with evidence suggesting that some observed effects may be indirect, mediated through AMPK activation and downstream NAD⁺ elevation. What is not in dispute is that resveratrol produces measurable effects on metabolic and inflammatory markers in multiple clinical trials, and that its combination with NAD⁺ precursors (NMN, NR) is an active area of clinical investigation. The ingredient's research depth - whatever the precise mechanism - remains unmatched in the longevity botanical category.

Q4: Is there an emodin safety concern for EU supplement products, and how do you address it?

This is a legitimate regulatory concern that deserves a direct answer. The European Food Safety Authority (EFSA) has flagged anthraquinone glycosides - including emodin and related compounds found in P. cuspidatum, aloe vera, and senna - as a category of concern, citing genotoxicity signals observed in in vitro assays. The in vivo relevance of these findings at typical dietary supplement exposure levels remains under evaluation, and no formal prohibition on P. cuspidatum extract in EU supplements has been issued as of the current regulatory cycle. However, several EU member states have issued precautionary guidance. Our practical response: we offer a low-emodin grade (emodin ≤ 1% by HPLC) specifically developed for EU-market supplement applications, produced through an additional purification step that selectively removes the anthraquinone fraction while preserving the stilbene content. Buyers targeting EU markets should specify this grade at the inquiry stage.

Q5: How does Polygonum Cuspidatum Extract compare to synthetic trans-resveratrol?

Synthetic trans-resveratrol - produced by chemical synthesis rather than botanical extraction - can achieve very high purity (> 99%) and consistent batch-to-batch composition. However, it carries two commercial disadvantages: it cannot be labeled as a botanical or plant-derived ingredient, which limits its appeal in the natural supplement and clean-label food markets; and it lacks the co-occurring phytochemical matrix (polydatin, emodin, flavonoids) that some formulators consider part of the ingredient's value proposition. For brands where "natural source" and "from Japanese knotweed root" are meaningful label claims - which covers the majority of the consumer supplement market - botanical P. cuspidatum extract is the commercially rational choice. For pharmaceutical or research applications where absolute purity and synthetic origin are acceptable, synthetic resveratrol may be appropriate.

Q6: What formulation challenges should I anticipate with high-purity trans-resveratrol powder?

Three practical challenges are worth flagging upfront. First, poor water solubility - trans-resveratrol aglycone has very low aqueous solubility (approximately 0.03 mg/mL at room temperature), which limits its use in liquid formulations without solubilization strategies (cyclodextrin complexation, micellar delivery, or switching to polydatin). Second, UV photosensitivity - as discussed above, UV exposure drives trans-to-cis isomerization; finished products should use opaque packaging. Third, bioavailability variability - resveratrol is rapidly metabolized in the gut and liver, with oral bioavailability of the free aglycone estimated at 25–75% depending on the delivery system and individual metabolic variation. Microencapsulated and liposomal-delivery grades are available from us for formulators seeking to address the bioavailability challenge directly.

Q7: Can Polygonum Cuspidatum Extract be used in cosmetic formulations?

Yes, and it is increasingly used in premium anti-aging skincare. Trans-resveratrol's antioxidant potency, combined with oxyresveratrol's documented anti-melanogenic activity (inhibition of tyrosinase), makes the extract relevant for both anti-aging and skin brightening applications. The primary formulation challenge in cosmetics is the same as in supplements: UV-induced isomerization and oxidative instability. For topical applications, encapsulated or stabilized resveratrol formats (liposomal, nanoparticle, or cyclodextrin-complexed) are recommended for products with a shelf life expectation of 24+ months. We can supply cosmetic-grade material with appropriate stability documentation on request.

Q8: What documentation is available to support regulatory submissions in the US and EU?

For US DSHEA submissions: P. cuspidatum root extract has a documented pre-DSHEA history of use as a dietary supplement ingredient, and trans-resveratrol from this source is listed in the NIH Dietary Supplement Label Database with multiple commercial precedents. We provide COA (per lot), botanical identity documentation, heavy metals and pesticide residue reports, solvent residue reports (ICH Q3C), microbiological test reports, trans/cis isomer ratio report, emodin content declaration, non-GMO declaration, and allergen statement. For EU submissions, we additionally provide a low-emodin grade COA and supporting documentation for regulatory dossiers. Our technical team can format documentation packages to align with common retailer qualification requirements.

Jiuyuan Biotech supplies Polygonum Cuspidatum Extract Powder to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

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