Baicalin Powder

Baicalin powder, a flavonoid compound, is extracted and isolated from the dried roots of Scutellaria baicalensis Georgi, a plant in the Lamiaceae family. It is one of the main active components of Scutellaria baicalensis. At room temperature, it appears as a pale yellow powder with a bitter taste.

Scutellaria baicalensis Georgi, commonly known as Huang Qin, is a traditional Chinese medicinal herb with a long history of therapeutic use. Its primary bioactive component, baicalin, is a flavonoid compound exhibiting a wide range of biological activities. In traditional Chinese medicine, Modern research has demonstrated that baicalin possesses anti-inflammatory, antioxidant, antibacterial, antiviral, anti-allergic, photoprotective, and skin-whitening effects, leading to its broad applications in the pharmaceutical and cosmetic fields. Baicalin present in Scutellaria baicalensis extract can effectively scavenge free radicals, inhibit melanin production, and enhance skin's antioxidant capacity. Furthermore, it exhibits significant ultraviolet (UV) absorption capabilities, positioning it as a potential natural sunscreen agent. Additionally, baicalin can modulate immune function and alleviate inflammatory responses, suggesting its beneficial effects on skin conditions such as atopic dermatitis.

At Jiuyuan Biotech, our Baicalin Powder is extracted from cultivated Scutellaria baicalensis roots grown in the Qinling Mountain region of Shaanxi Province - an area whose soil mineral profile and altitude produce roots with naturally elevated baicalin content. Every batch is standardized by HPLC and shipped with a full COA covering assay, heavy metals, pesticide residues, solvents, and microbiology.

Below is the COA of baicalin powder, please refer to it.

Baicalin does not operate in isolation. The root of Scutellaria baicalensis contains a constellation of flavonoids, and understanding the full phytochemical context helps formulators make better decisions:

On Baicalin vs. Baicalein: A common point of confusion for new buyers. Baicalin is the glycoside form - more stable, higher yield from extraction, and the standard commercial form. Baicalein is its aglycone (de-glycosylated) metabolite, produced in the gut by microbial action or in vitro by enzymatic hydrolysis. Some formulators prefer baicalein for applications targeting enhanced bioavailability, though baicalin remains the dominant commercial specification.

Our extraction process is neither outsourced nor abbreviated. Here's how baicalin moves from root to drum at our Shaanxi facility:

1. Raw Material Selection & Incoming QC Roots are sourced from contracted farms within a 200 km radius of our plant. Each incoming lot is tested for identity (TLC/HPLC), moisture, and pesticide residues before entering production.

2. Pre-Treatment & Comminution Dried roots are cleaned, sorted, and milled to a defined particle size to maximize extraction surface area and minimize solvent consumption.

3. Solvent Extraction We use food-grade ethanol as the primary extractant. Extraction parameters - temperature, solvent-to-material ratio, and contact time - are validated and locked per product specification. No chlorinated solvents are used.

4. Filtration & Concentration The crude extract is filtered through multi-stage systems and concentrated under reduced pressure (vacuum evaporation) to preserve thermolabile constituents.

5. Purification & Crystallization For high-purity grades (≥95%), the concentrated extract undergoes column chromatography or recrystallization to remove co-extracted impurities and achieve target assay values.

6. Spray Drying / Vacuum Drying The purified extract is dried using controlled spray-drying or vacuum-drying depending on the target grade, yielding a consistent, free-flowing powder.

7. Milling, Sieving & Blending Final powder is milled to specification, sieved to 80 mesh (or custom), and blended for batch homogeneity.

8. In-Process & Final QC Every batch undergoes in-house HPLC assay, microbiological testing, and heavy metal screening before release. Third-party verification is available on request.

Baicalin's multifunctional profile makes it relevant across several distinct market verticals. Below is a practical breakdown for procurement and formulation teams:

*Dosage ranges are provided for formulation reference only and do not constitute medical or regulatory advice. Formulators should consult applicable regulatory frameworks (FDA, EFSA, etc.) for their specific market.

Why formulators choose baicalin over generic antioxidants: Unlike commodity antioxidants such as vitamin C or generic polyphenol blends, baicalin offers a defined, quantifiable active compound with a traceable botanical origin and a growing body of peer-reviewed mechanistic research - attributes that increasingly matter to premium supplement brands and their retail buyers.

Full certificate copies are available upon request or via our secure document portal. NDA/CDA signing is supported for buyers requiring confidentiality during qualification.

One of the most persistent pain points among supplement buyers is grade confusion - paying for 85% and receiving something that performs like 60%, or overpaying for 98% when 85% fully meets the application requirement. Here's a transparent breakdown:

The honest answer on 98%: Unless your application genuinely requires pharmaceutical reference-grade material, 85%–90% HPLC baicalin delivers equivalent functional performance in supplement and cosmetic applications at a significantly lower cost per kilogram. We will tell you this upfront - because the right specification for your product is the one that serves your formulation, not our margin.

Shaanxi Jiuyuan Biotechnology Co., Ltd., in addition to producing plant extracts, mainly does OEM for major manufacturers. The factory covers an area of more than 70,000 square meters, equipped with 6 production workshops, 10 production lines, 1 R&D technology center, and many advanced testing equipment, with an annual production capacity of more than 6,000 tons. We have obtained cGMP, ISO9001 quality management system certification, ISO22000 food safety management system, HACCP certification, US FDA inspection certification, FSSC22000, Halal certification, Kosher certification, USDA/EU Organic Certificates, and other qualifications and certifications, so we are the best supplier choice.

Q1: What is the difference between baicalin and baicalein? Baicalin (CAS 21967-41-9) is a flavonoid glycoside - it has a glucuronide sugar group attached to the baicalein aglycone. In the body, intestinal microbiota hydrolyze baicalin into baicalein, which is then absorbed. Commercially, baicalin is the standard extract form due to higher yield and stability. Baicalein (CAS 491-67-8) is available as a separate product for applications requiring the aglycone form directly.

Q2: Is your baicalin powder water-soluble? Standard baicalin has limited aqueous solubility (approximately 0.2 mg/mL in neutral water). For water-dispersible applications - beverages, effervescent tablets, or liquid formulations - we offer a cyclodextrin-complexed or spray-dried dispersion form with significantly improved dispersibility. Inquire for technical details and pricing.

Q3: Does your product comply with EU regulations for botanical extracts? Yes. Our baicalin powder is produced in compliance with EU Regulation 396/2005 on pesticide maximum residue levels and is accompanied by documentation supporting EU market entry. Buyers targeting the EU market should note that Scutellaria baicalensis extract is on the EU Botanical Compendium; we recommend consulting your regulatory counsel for the specific product category.

Q4: How do you ensure batch-to-batch consistency? Consistency starts at the raw material stage - we source from contracted farms with defined cultivation protocols. In-process HPLC monitoring at extraction and post-drying stages ensures the assay stays within specification. Each batch is assigned a unique lot number with full traceability back to the source field.

Q5: Can I get a sample before placing a bulk order? Absolutely. We offer analytical samples (100 g) and formulation samples (up to 1 kg) for qualified buyers. Samples ship with a full COA. Contact our sales team with your company details and intended application to initiate the sample request.

Q6: What certifications are relevant for selling baicalin-containing products in the U.S. market? For dietary supplement applications, the key compliance framework is 21 CFR Part 111 (cGMP for dietary supplements). Our facility is FDA-registered and cGMP-compliant. We provide the documentation - COA, MSDS, allergen declaration, country of origin - that your QA team needs for supplier qualification under 21 CFR 111.75.

Q7: Is baicalin considered safe for long-term use in supplements? Baicalin has a long history of use in Traditional Chinese Medicine as part of Huang Qin (Scutellaria root). Contemporary safety data, including published toxicological studies, support its use in supplement applications at established dosage ranges. That said, formulation-level safety assessments remain the responsibility of the finished product manufacturer, and we recommend reviewing the relevant literature and consulting a qualified toxicologist for your specific application.

Q8: Do you offer private label or white-label services? Our core business is bulk ingredient supply. We do not offer finished product manufacturing or private label capsules/tablets. We focus on being the best possible upstream partner - so that your downstream product is built on a reliable, verified foundation.

Jiuyuan Biotech supplies baicalin powder to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

Request: Sample| Bulk Quote | CoA & Spec Sheet | Custom Carrier Ratio

Standard response time: within 1 business day. Please include your target application and annual volume estimate for the most relevant technical recommendation.