Andrographis Extract Powder

Andrographis extract powder is derived from the aerial parts of Andrographis paniculata (Burm. f.) Nees, an annual herbaceous plant widely used in traditional Asian medicine. Andrographolide, a diterpenoid compound, is the primary active constituent, exhibiting a range of bioactivities, including antimicrobial, antioxidant, antimalarial, anti-angiogenic, anti-inflammatory, and anti-diabetic properties.

The extraction processes for Andrographis are diverse. Common methods employed by Jiuyuan Biology include solvent extraction, ultrasonic extraction, and microwave extraction. These techniques effectively enhance extraction efficiency and product purity. 

Mechanism of Action: Andrographolide's mechanisms involve the modulation of various signaling pathways, such as NF-κB, MAPK, and PI3K/Akt.

Below is the COA of Andrographis extract powder, please refer to it.

1. Antiviral effect

Andrographolide, the main active ingredient in Andrographis extract, has an inhibitory effect on a variety of viruses. For example, it can inhibit the replication of influenza virus and reduce the inflammatory response caused by the virus.

The extract and its derivatives show good antiviral activity against a variety of respiratory viruses in vitro and can be used to treat respiratory viral infections such as the common cold and influenza.

2. Anti-inflammatory effect

It has a significant anti-inflammatory effect. It inhibits the production and release of inflammatory factors and reduces symptoms such as redness, swelling, heat, and pain at the site of inflammation. For example, acute respiratory infections, can reduce the level of inflammatory mediators and relieve the inflammatory response of the respiratory tract.

It can also enhance the body's resistance to inflammation by regulating the immune system. It can activate immune cells and improve the body's immune function, to better cope with inflammation.

3. Immunomodulatory effect

It can regulate the immune system and enhance the body's immune function. It can stimulate the proliferation and differentiation of immune cells and increase the production of antibodies, thereby enhancing the body's resistance to pathogens.

It can also regulate the balance of the immune system to avoid damage to the body caused by excessive immune response. In some immune-related diseases, Andrographis paniculata extract can play an immunomodulatory role and alleviate symptoms.

4. Heat-clearing and detoxifying effect

It has the effect of clearing heat and detoxifying. In traditional medicine, Andrographis is widely used to treat heat-toxic diseases, such as sore throat, fever, and headache. It can relieve the discomfort caused by heat and toxicity through the effect of clearing heat and detoxifying.

5. Antioxidant effect

It has antioxidant activity. It can remove free radicals in the body and reduce the damage to cells caused by oxidative stress. This antioxidant effect helps to protect the normal function of cells and prevent a variety of chronic diseases.

• Pharmaceutical Industry

Traditional Medicine: In traditional medical systems such as Ayurveda and Chinese Medicine, Andrographis paniculata is used to treat a variety of diseases such as fever, inflammation, infection and digestive system diseases. For example, in Ayurveda, a decoction made from Andrographis paniculata leaves can be used to reduce fever and enhance the body's resistance to disease.

Modern Pharmaceuticals: Andrographis extract has multiple pharmacological activities such as antibacterial, anti-inflammatory, and immunomodulatory, and is a valuable resource for the development of new drugs and therapies. Its antibacterial activity makes it a potential candidate for the development of new antibacterial drugs that can inhibit the growth of a variety of bacteria, viruses and fungi. In addition, it can also be used to treat inflammatory diseases, regulate the immune system, etc.

• Agricultural Field

It has antibacterial and anti-insect properties, so it can be used as a natural insecticide or fungicide in agriculture. The use of natural products such as Andrographis extract can reduce the use of synthetic insecticides and fungicides, which are often harmful to the environment and human health. In addition, it can also be used to promote plant growth and enhance plant resistance to disease.

• Cosmetic Industry

It has antioxidant and anti-inflammatory properties, which makes it a potential ingredient in the cosmetic industry. It can be used in skin care products such as creams, lotions and serums, which can be formulated to target skin problems such as acne, inflammation and premature aging.

• Health Supplement Industry

The extract has also found a place in the health supplement industry as the demand for natural health products increases. It can be added to dietary supplements in the form of capsules, tablets or powders. These products are advertised to have a variety of health benefits such as boosting the immune system, improving digestion and providing antioxidant protection.

Not all andrographis ingredients on the market are equivalent. The table below maps the key differentiators buyers should evaluate:

The standardized whole-extract format occupies the optimal position for most supplement manufacturers: it retains the synergistic phytochemical matrix, delivers verified andrographolide content for label claims, and carries the regulatory documentation that EU and US markets require.

1. Raw Material Advantages
Jiuyuan Biology has established exclusive medicinal herb cultivation bases in the Qinling Mountains, ensuring the quality of raw materials from the source. This geographical advantage enables the company to control the quality and supply stability of raw materials, providing a fundamental guarantee for the production of high-quality Andrographis paniculata extract.

2. Production Facilities and Processes
Jiuyuan Biology has invested in the construction of a modern industrial plant covering approximately 70,000 square meters, featuring a testing and control center of over 1,000 square meters, with 6 production workshops, 10 production lines, 1 R&D technology center, and many advanced testing equipment. The annual production capacity can reach an average of more than 6,000 tons. The company employs advanced production equipment and processes, with production operations strictly adhering to GMP operational guidelines to ensure product safety, stability, and consistency.

The Real Pain Points in Sourcing Andrographis Extract

"Our last supplier's COA showed 10% andrographolide - but our contract lab got 4%." This is the single most common complaint we hear from new clients. Colorimetric assay methods can significantly overestimate andrographolide content compared to HPLC. At Jiuyuan, andrographolide is quantified exclusively by HPLC - the same method your contract lab will use. What our COA says is what your lab will find.

"We need EU Traditional Herbal Medicinal Product (THMP) documentation support." EU THMP registration for A. paniculata preparations requires a well-documented extract with consistent specification. We can provide full technical dossiers including extraction ratio, solvent declaration, andrographolide content, and stability data to support your regulatory submission.

"Seasonal demand spikes mean we need reliable lead times." Immune-support ingredients see sharp demand surges in Q3–Q4. We maintain strategic buffer inventory on andrographis extract specifically because of this seasonality. Standard lead time is 2–3 weeks post-order; pre-season reservation orders can be accommodated.

"We need a supplier who can grow with us from pilot to commercial scale." Our MOQ is 25 kg for qualification batches. We support scale-up through pilot (25–100 kg), commercial launch (100–500 kg), and high-volume supply (500 kg+) without requiring re-qualification at each stage.

How to Order

• Specify your grade - andrographolide percentage (10% / 20% / 50%), organic or conventional, particle size
• Request a sample - 50–200g samples available for formulation and lab verification
• Review documentation - COA, HPLC report, MSDS, certificates sent within 24h
• Receive formal quotation - FOB Shenzhen / Shanghai, CIF, or DDP pricing available
• Confirm order - batch-specific COA and HPLC report issued pre-shipment

Q1: What andrographolide percentages do you offer, and which is right for my application? We supply standardized extracts at 10%, 20%, and 50% andrographolide by HPLC. The 10% grade is the most widely used in dietary supplement capsules and tablets, offering a practical balance between potency, cost, and formulation handling. The 20% grade suits applications where a smaller serving size is commercially important. The 50% grade is used in pharmaceutical-grade formulations, high-potency products, or as a blending base.

Q2: How do you verify andrographolide content - HPLC or UV? All our standardization claims are based on HPLC quantification, not UV spectrophotometry or colorimetric methods. UV methods are faster but less selective - they measure total UV-absorbing compounds, which can include structurally similar diterpenoids that inflate the apparent andrographolide reading. HPLC separates and quantifies andrographolide specifically. This is why our in-house COA values align with third-party contract lab results.

Q3: Is your extraction process solvent-free or does it use ethanol? Our standard extraction process uses food-grade ethanol/water mixtures - the same solvent system used in the vast majority of published andrographis extraction research and validated pharmaceutical manufacturing. Residual solvent testing is performed per ICH Q3C on every batch, and levels are consistently well within USP and EU pharmacopoeia limits. No residual solvent concern has been flagged in any third-party audit of our facility.

Q4: Is Andrographis paniculata extract regulated as a novel food in the EU? Andrographis paniculata has a documented history of use in herbal medicine within Europe and is not classified as a novel food under EU Regulation 2015/2283. It can be marketed as a food supplement ingredient in EU member states, subject to national regulations. For Traditional Herbal Medicinal Product (THMP) registration, a 30-year documented traditional use period (including 15 years within the EU) is required. Buyers are advised to verify current regulatory status with their local competent authority, as requirements vary by country and application type.

Q5: What is the recommended storage condition to maintain andrographolide stability? Andrographolide is relatively stable under standard storage conditions but is sensitive to prolonged heat and moisture exposure. We recommend storing sealed drums at ≤ 25°C in a dry environment away from direct light. Under these conditions, shelf life is 24 months from manufacture date. Once opened, reseal promptly and use within a reasonable timeframe. Stability data is available upon request.

Q6: Can you supply certified organic Andrographis Extract Powder? Yes. Certified organic andrographis extract is available under both USDA NOP and EU Organic certification. Organic-grade product is processed from raw material grown without synthetic pesticides or fertilizers on certified cultivation land. Lead time for organic grade may be slightly longer than conventional; confirm availability and pricing when requesting a quote.

Q7: Do you have clinical study references to support label claims for immune support? Yes. The immune-modulating properties of andrographolide are among the most extensively documented in the botanical supplement literature. A comprehensive review published in Molecules (MDPI, 2022) summarized the pharmacological evidence across immune, anti-inflammatory, and antiviral activities. Clinical studies on A. paniculata extract in upper respiratory tract infections have been published in peer-reviewed journals and are frequently cited in EU THMP dossiers. We can provide a curated reference package to support your regulatory and marketing teams.

Q8: What is the minimum order for a sample, and how long does shipment take? Samples of 50–200g are available for qualified buyers at no charge (freight at buyer's cost). Sample shipments via DHL/FedEx typically arrive within 5–7 business days to North America and Europe. A full documentation package - COA, HPLC report, MSDS, and relevant certificates - accompanies every sample.

ByAir

100kg-1000kg, 5-7Days

Airport-to-airport service professional

clearance broker needed

BySea

Over300kg, Around 30 Days

Port-to-port service professional

clearance broker needed

Express

Under 100kg, 3-5Days

Door-to-door service easy to pick up the goods

We provide a variety of packaging including aluminum foil bags, paper boxes, plastic barrels, etc. According to your specific requirements, we can also customize the packaging specifications and designs to ensure that the products are not damaged during transportation. We have established long-term cooperative relationships with many well-known international logistics companies, and the transportation process is efficient and safe.

Jiuyuan Biotech has supplied standardized botanical extracts to supplement manufacturers, contract formulators, and pharmaceutical companies across 30+ countries since 2012. Our facility operates 10 production lines with full in-house QC - no brokers, no subcontracted manufacturing, no generic paperwork.

If you're evaluating Andrographis Extract Powder for your next immune-support formulation, request a sample and technical package today. Our team responds within one business day.

📞 +86 029 88215052 🌐 www.jiuyuanbio.com  Email: info@jiuyuanbio.com