Codonopsis Extract

Codonopsis Extract

CAS No.: 4431-01-0
Other Names:Yungui, Western Angelica
Latin name: Angelica sinensis (Oliv.) Diels.
Plant parts:Root
Appearance:brown yellow fine powder
Specification:10:1 20:1 30:1 50:1
MOQ: 1kg
Application:Food,beverages,cosmetics, medicines‌
Certificate:cGMP,USDA/EU Organic,ISO9001,ISO22000,HACCP,FSSC22000, KOSHER, HALAL
Standard Specifications:10:1 ratio; Polysaccharides ≥30%; Lobetyolin ≥0.1% (HPLC)
Appearance:Light yellow to tan-brown fine powder
Solubility: Readily soluble in water; partially soluble in ethanol
Mesh Size: 80 mesh (customizable)
MOQ: 25 kg
Shelf Life:24 months (sealed, stored below 25°C, away from light)
Packaging: 25 kg fiber drums with double PE inner liner
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Description
Technical Parameters

Codonopsis pilosula Extract (Dangshen Extract) – Standardized Root Powder

Codonopsis extract, also known as Dangshen extract, is a concentrated powder derived from the dried roots of Codonopsis pilosula (Franch.) Nannf., a member of the Campanulaceae family. Commonly referred to as the "poor-man's ginseng," this extract is standardized to 5:1, 10:1, or 20:1 concentrations and provides ≥30% crude polysaccharides along with characteristic saponins such as Lancemaside A and Tangshenoside I–III.

The powder is 100% water-soluble, vegan, gluten-free, and available with EU & USDA Organic certification, making it suitable for:

  • Adaptogenic capsules and tablets
  • Functional beverages
  • Clinical nutrition formulas
  • Cosmeceutical applications

Quick Overview: Supports energy, immune balance, and mucosal health in a standardized, easy-to-formulate extract.

Codonopsis pilosula

 

Active Components & Mechanisms

Component (typical) Content (HPLC/UV) Mode of Action Evidence Snapshot (2025)
Crude Polysaccharides 30–50 % May activate PI3K-Akt & MAPK signaling → supports intestinal stem-cell proliferation and mucosal repair Randomized, double-blind trial (n=120) showed 28% reduction in subjective fatigue after 4 weeks at 1 g/day
Lancemaside A 0.6–1.1 % Gut-microbiome conversion to echinocystic acid → may inhibit NF-κB & NLRP3 → supports anti-inflammatory response In vivo: 50 mg/kg ↑ hippocampal SOD, ↓ MDA, improved cognitive scores
Tangshenoside I–III 0.3–0.7 % May modulate JAK/STAT and VEGFA pathways → supports micro-circulation and immune homeostasis Network-pharmacology study identified AKT1, IL-6, TNF-α as top hubs
Codonoside & β-carboline alkaloids <0.1 % Mild monoamine oxidase inhibition → may provide gentle mood support Anxiolytic activity demonstrated in zebrafish light-dark test

Disclaimer: These statements have not been evaluated by the FDA. This ingredient is not intended to diagnose, treat, cure, or prevent any disease.

 

Specifications & Quality Control

Item Specification Method Remark
Extract ratio 5:1, 10:1, 20:1 Weight balance Custom 30:1–50:1 available
Polysaccharides ≥30 % (UV) Phenol-sulfuric acid COA per batch
Lancemaside A ≥0.5 % (HPLC) In-house JY-2025-04 Peak area vs. reference standard
Appearance Brown-yellow, 80–120 mesh Visual & sieve Free-flowing, hygroscopic
Solubility 100 % water-soluble 1 g/10 mL 25 °C Clear, no precipitate
Heavy metals Pb ≤0.5 ppm, Cd ≤0.3 ppm, As ≤0.2 ppm ICP-MS Conforms to USP<232>
Microbial TAMC ≤1,000 CFU/g, TYMC ≤100 CFU/g, Salmonella absent /10 g, E. coli absent /10 g CP2020 & USP<2021> Gamma-irradiation not used
Pesticides 228 multi-residue ≤0.01 ppm LC-MS/MS Meet EC 396/2005
Shelf life 24 months Stability study 40 °C / 75 % RH Packed in 1 kg foil + 25 kg drum
Certificates USDA ORGANIC, EU 834/2007, cGMP, ISO 22000, ISO9001, HACCP, FSSC22000, KOSHER, HALAL

 

Extraction & Processing Methods

Raw Herb Selection

Roots harvested at ≥1,800 m altitude in Min County, Gansu

Quick-dried within 24 h to ≤12% moisture to minimize mold and endotoxin

Low-Temperature Reflux Extraction

Stage 1: 60% ethanol, 55 °C, 2 h → de-fatting & saponin enrichment

Stage 2: Purified water, 90 °C, 3 h → polysaccharide release

Yield: 18–22% soluble solids

Vacuum Concentration & Spray-Drying

Concentrated to 35 °Brix under −0.08 MPa

Spray-dried (inlet 160 °C, outlet 75 °C) with 3% maltodextrin → free-flowing powder, moisture ≤5%

Solvent-Free & Vegan

No excipients except maltodextrin

Non-GMO, non-irradiated, gluten-free, <0.1 ppm solvent residue.

Spray drying process flow chart

 

Applications

Codonopsis Extract fits cleanly into multiple product categories - which is part of what makes it a commercially versatile ingredient for formulators.

Application Category

Typical Format

Recommended Dosage Range

Key Selling Point

Immune Support Supplements

Capsule, tablet, softgel

300–600 mg/day

Polysaccharide-driven immune modulation

Adaptogen / Stress Blends

Capsule, tincture, powder blend

400–800 mg/day

Pairs well with Astragalus, Reishi, Ashwagandha

Gut Health Formulas

Capsule, functional beverage

250–500 mg/day

Lobetyolin gastroprotective activity

TCM-Inspired Nutraceuticals

Capsule, granule, tea blend

500–1000 mg/day

Authentic Dang Shen provenance

Functional Foods & Beverages

Powder, ready-to-mix

200–400 mg/serving

Mild flavor profile, water-soluble

Sports Nutrition / Energy

Capsule, stick pack

300–600 mg/day

Fatigue reduction, qi-tonifying tradition

Senior Wellness Products

Capsule, soft chew

300–500 mg/day

Cardiovascular & cognitive support research

Formulator's Note: Codonopsis Extract pairs particularly well with Astragalus membranaceus extract in immune formulas - a combination with deep roots in classical TCM and growing clinical interest in the West. Both are available from Jiuyuan Biotech with matched lot documentation for co-ingredient traceability.

 

Comparison: Codonopsis Extract vs. Competing Adaptogen Ingredients

One of the most common questions from formulators: how does Codonopsis stack up against Astragalus or Panax Ginseng in a formula context? Here's an honest, side-by-side view:

Parameter

Codonopsis Extract

Astragalus Extract

Panax Ginseng Extract

Primary Actives

Polysaccharides, Lobetyolin

Astragalosides, Polysaccharides

Ginsenosides (Rb1, Rg1)

Immune Modulation

✅ Strong

✅ Strong

✅ Moderate–Strong

Adaptogenic Activity

✅ Moderate

✅ Moderate

✅ Strong

Gastroprotective

✅ Yes (Lobetyolin)

❌ Limited

❌ Limited

Stimulant Effect

Low (well-tolerated)

Very Low

Moderate–High

Cost Index (relative)

● Low–Medium

● Low–Medium

●●● High

Market Familiarity (West)

Growing

Established

Very High

TCM Tradition

Deep (Qi tonic)

Deep (Wei Qi)

Deep (Yuan Qi)

Typical Label Claim

Immune, Energy, Gut

Immune, Longevity

Energy, Cognitive

Takeaway for formulators: Codonopsis is the pragmatic choice when you need the immune + adaptogenic profile of ginseng without the stimulant liability or cost burden - and when gastroprotective positioning adds formula differentiation.

 

Why Choose Shaanxi Jiuyuan Biotechnology?

  • 70,000㎡ production area with 10 production lines, annual capacity >6,000 tons
  • 12-person R&D team, 500㎡ advanced laboratory
  • State-of-the-art equipment: Plate-frame & disc centrifuge, dry granulation, ultrafine milling
  • Strict QC from raw material to final extract
  • Multiple certifications: cGMP, ISO, HACCP, FSSC22000, Halal, Kosher, USDA/EU Organic
  • Trusted global B2B supplier for standardized, high-quality botanical extracts

Regulatory Note: Please comply with local regulatory requirements for dietary supplements, functional foods, and nutraceuticals.

jiuyuan biotech advantages

 

Quality Control

We operate an in-house analytical laboratory equipped for the full testing panel required by US, EU, and global supplement markets. This is not outsourced - it is on-site, batch-specific, and documented.

Analytical Methods Employed:

  • HPLC - Lobetyolin assay, pesticide residue screening
  • UV-Vis Spectrophotometry - Polysaccharide quantification
  • TLC (Thin Layer Chromatography) - Identity confirmation per Chinese Pharmacopoeia 2020 monograph
  • ICP-MS - Heavy metal quantification (Pb, As, Hg, Cd)
  • GC-MS - Residual solvent analysis
  • Microbiological Testing - Total plate count, yeast/mold, E. coli, Salmonella

Reference Standards: All assay methods are referenced against Chinese Pharmacopoeia (ChP 2020), United States Pharmacopeia (USP), and European Pharmacopoeia (EP) where applicable.

Batch Traceability: Every production batch carries a unique lot number traceable from the raw material intake record through to the final COA. Clients receive full documentation packages including raw material certificates, in-process records, and finished product COA.

jiuyuan biotech R&D center

 

Certificates & Documents

Jiuyuan Biotech holds 12 internationally recognized certifications relevant to supplement ingredient supply:

Certificate

Issuing Body

Scope

ISO 9001:2015

Third-party accredited body

Quality Management System

FSSC 22000

FSSC Foundation

Food Safety Management

ISO 22000

Third-party accredited body

Food Safety Management System

Kosher

Recognized Kosher agency

Dietary compliance

Halal

Recognized Halal certification body

Dietary compliance

HACCP

Third-party audited

Hazard analysis & critical control

Organic Certification

NOP / EU Organic (select products)

Organic supply chain

Documents Available Upon Request:

  • Certificate of Analysis (COA) - batch-specific
  • Certificate of Origin (COO)
  • Material Safety Data Sheet (MSDS / SDS)
  • Allergen Declaration
  • GMO Statement
  • BSE/TSE Statement
  • Pesticide Residue Test Report
  • Heavy Metal Test Report
  • Stability Data

 

FAQ

Q: What is the difference between Dang Shen and Ginseng?
A: Dang Shen (Codonopsis pilosula) is milder than ginseng, often used to support energy and immunity without overstimulation.

Q: How much polysaccharide is in 10:1 Codonopsis extract?
A: Typically ranges from 5% to 10%, depending on batch and extraction method.

Q: Can Codonopsis extract be used in beverages?
A: Yes, it dissolves well in water and can be added to teas, drinks, and functional beverages.

Q: What is the recommended dosage for health supplements?
A: Commonly 1–3 g per day for adults; follow regulatory guidelines and product-specific labeling.

Q: How is the extract standardized?
A: Via polysaccharide content testing and HPLC verification to ensure consistent bioactivity.

Q: Are there clinical studies supporting its immune benefits?
A: Yes, multiple studies demonstrate its immunomodulatory effects (see references above).

Q: What is the shelf life and storage condition?
A: 24 months if stored in a cool, dry, dark environment.

Q: Is Codonopsis Extract safe for long-term use?
A: Generally considered safe when used as a dietary supplement; consult healthcare professionals for specific health conditions.

 

Packaging and transportation advantages

air transport

ByAir

100kg-1000kg, 5-7Days

Airport to airport service professional

clearance broker needed

Ocean Freight

BySea

Over300kg, Around 30 Days

Port to port service professional

clearance broker needed

ems

Express

Under 100kg, 3-5Days

Door-to-door service easy to pick up the goods

We offer a variety of packaging options, including aluminum foil bags, paper boxes, plastic barrels, etc., to meet the needs of different customers. According to your specific requirements, we can customize the packaging specifications and designs to ensure that the products are not damaged during transportation.

We have established long-term cooperative relationships with many well-known logistics and express companies to ensure the efficiency and safety of the transportation process. Our logistics partners are all equipped with professional transportation equipment and experience, and can provide reliable transportation services.

jiuyuan biotech warehouse

 

Request a Sample or Commercial Quote

Jiuyuan Biotech supplies Codonopsis Extract to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

Request: Sample| Bulk Quote | CoA & Spec Sheet | Custom Carrier Ratio

Standard response time: within 1 business day. Please include your target application and annual volume estimate for the most relevant technical recommendation.

 

 

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