Codonopsis Extract
Other Names:Yungui, Western Angelica
Latin name: Angelica sinensis (Oliv.) Diels.
Plant parts:Root
Appearance:brown yellow fine powder
Specification:10:1 20:1 30:1 50:1
MOQ: 1kg
Application:Food,beverages,cosmetics, medicines
Certificate:cGMP,USDA/EU Organic,ISO9001,ISO22000,HACCP,FSSC22000, KOSHER, HALAL
Codonopsis pilosula Extract (Dangshen Extract) – Standardized Root Powder
Codonopsis (pilosula) extract, also known as Dangshen extract, is a concentrated powder derived from the dried roots of Codonopsis pilosula (Franch.) Nannf., a member of the Campanulaceae family. Commonly referred to as the "poor-man's ginseng," this extract is standardized to 5:1, 10:1, or 20:1 concentrations and provides ≥30% crude polysaccharides along with characteristic saponins such as Lancemaside A and Tangshenoside I–III.
The powder is 100% water-soluble, vegan, gluten-free, and available with EU & USDA Organic certification, making it suitable for:
- Adaptogenic capsules and tablets
- Functional beverages
- Clinical nutrition formulas
- Cosmeceutical applications
Quick Overview: Supports energy, immune balance, and mucosal health in a standardized, easy-to-formulate extract.
Active Components & Mechanisms
| Component (typical) | Content (HPLC/UV) | Mode of Action | Evidence Snapshot (2025) |
|---|---|---|---|
| Crude Polysaccharides | 30–50 % | May activate PI3K-Akt & MAPK signaling → supports intestinal stem-cell proliferation and mucosal repair | Randomized, double-blind trial (n=120) showed 28% reduction in subjective fatigue after 4 weeks at 1 g/day |
| Lancemaside A | 0.6–1.1 % | Gut-microbiome conversion to echinocystic acid → may inhibit NF-κB & NLRP3 → supports anti-inflammatory response | In vivo: 50 mg/kg ↑ hippocampal SOD, ↓ MDA, improved cognitive scores |
| Tangshenoside I–III | 0.3–0.7 % | May modulate JAK/STAT and VEGFA pathways → supports micro-circulation and immune homeostasis | Network-pharmacology study identified AKT1, IL-6, TNF-α as top hubs |
| Codonoside & β-carboline alkaloids | <0.1 % | Mild monoamine oxidase inhibition → may provide gentle mood support | Anxiolytic activity demonstrated in zebrafish light-dark test |
Disclaimer: These statements have not been evaluated by the FDA. This ingredient is not intended to diagnose, treat, cure, or prevent any disease.
References:
- Li X, et al., Codonopsis pilosula polysaccharides: pharmacological activities and mechanisms. PubMed
- Wang Y, et al., Bioactive compounds of Codonopsis pilosula and their immunomodulatory effects. PMC
- Zhang H, et al., Codonopsis pilosula polysaccharides in health supplements. PubMed
Specifications & Quality Control
| Item | Specification | Method | Remark |
| Extract ratio | 5:1, 10:1, 20:1 | Weight balance | Custom 30:1–50:1 available |
| Polysaccharides | ≥30 % (UV) | Phenol-sulfuric acid | COA per batch |
| Lancemaside A | ≥0.5 % (HPLC) | In-house JY-2025-04 | Peak area vs. reference standard |
| Appearance | Brown-yellow, 80–120 mesh | Visual & sieve | Free-flowing, hygroscopic |
| Solubility | 100 % water-soluble | 1 g/10 mL 25 °C | Clear, no precipitate |
| Heavy metals | Pb ≤0.5 ppm, Cd ≤0.3 ppm, As ≤0.2 ppm | ICP-MS | Conforms to USP<232> |
| Microbial | TAMC ≤1,000 CFU/g, TYMC ≤100 CFU/g, Salmonella absent /10 g, E. coli absent /10 g | CP2020 & USP<2021> | Gamma-irradiation not used |
| Pesticides | 228 multi-residue ≤0.01 ppm | LC-MS/MS | Meet EC 396/2005 |
| Shelf life | 24 months | Stability study 40 °C / 75 % RH | Packed in 1 kg foil + 25 kg drum |
| Certificates | USDA ORGANIC, EU 834/2007, cGMP, ISO 22000, ISO9001, HACCP, FSSC22000, KOSHER, HALAL | ||
Extraction & Processing Methods
Raw Herb Selection
Roots harvested at ≥1,800 m altitude in Min County, Gansu
Quick-dried within 24 h to ≤12% moisture to minimize mold and endotoxin
Low-Temperature Reflux Extraction
Stage 1: 60% ethanol, 55 °C, 2 h → de-fatting & saponin enrichment
Stage 2: Purified water, 90 °C, 3 h → polysaccharide release
Yield: 18–22% soluble solids
Vacuum Concentration & Spray-Drying
Concentrated to 35 °Brix under −0.08 MPa
Spray-dried (inlet 160 °C, outlet 75 °C) with 3% maltodextrin → free-flowing powder, moisture ≤5%
Solvent-Free & Vegan
No excipients except maltodextrin
Non-GMO, non-irradiated, gluten-free, <0.1 ppm solvent residue.
Applications
| Sector | Suggested Use Level | Function |
|---|---|---|
| Adaptogenic capsules | 300–500 mg/day | Energy support, anti-fatigue |
| Functional beverages | 0.8–1.2 g/L (dry wt.) | Clear solution, neutral taste |
| Clinical nutrition | 1–3 g/day (enteral) | Supports mucosal repair, gut-immune axis |
| Cosmeceuticals | 0.5–2 % in emulsion | Anti-redness, neuro-soothing |
| Veterinary / swine | 500 ppm in feed | ↑ daily gain, ↑ IgG |
Why Choose Shaanxi Jiuyuan Biotechnology
- 70,000㎡ production area with 10 production lines, annual capacity >6,000 tons
- 12-person R&D team, 500㎡ advanced laboratory
- State-of-the-art equipment: Plate-frame & disc centrifuge, dry granulation, ultrafine milling
- Strict QC from raw material to final extract
- Multiple certifications: cGMP, ISO, HACCP, FSSC22000, Halal, Kosher, USDA/EU Organic
- Trusted global B2B supplier for standardized, high-quality botanical extracts
Regulatory Note: Please comply with local regulatory requirements for dietary supplements, functional foods, and nutraceuticals.
FAQ
Q: What is the difference between Dang Shen and Ginseng?
A: Dang Shen (Codonopsis pilosula) is milder than ginseng, often used to support energy and immunity without overstimulation.
Q: How much polysaccharide is in 10:1 Codonopsis extract?
A: Typically ranges from 5% to 10%, depending on batch and extraction method.
Q: Can Codonopsis extract be used in beverages?
A: Yes, it dissolves well in water and can be added to teas, drinks, and functional beverages.
Q: What is the recommended dosage for health supplements?
A: Commonly 1–3 g per day for adults; follow regulatory guidelines and product-specific labeling.
Q: How is the extract standardized?
A: Via polysaccharide content testing and HPLC verification to ensure consistent bioactivity.
Q: Are there clinical studies supporting its immune benefits?
A: Yes, multiple studies demonstrate its immunomodulatory effects (see references above).
Q: What is the shelf life and storage condition?
A: 24 months if stored in a cool, dry, dark environment.
Q: Is Codonopsis Extract safe for long-term use?
A: Generally considered safe when used as a dietary supplement; consult healthcare professionals for specific health conditions.
Packaging and transportation advantages
ByAir
100kg-1000kg, 5-7Days
Airport to airport service professional
clearance broker needed
BySea
Over300kg, Around 30 Days
Port to port service professional
clearance broker needed
Express
Under 100kg, 3-5Days
Door-to-door service easy to pick up the goods
We offer a variety of packaging options, including aluminum foil bags, paper boxes, plastic barrels, etc., to meet the needs of different customers. According to your specific requirements, we can customize the packaging specifications and designs to ensure that the products are not damaged during transportation.
We have established long-term cooperative relationships with many well-known logistics and express companies to ensure the efficiency and safety of the transportation process. Our logistics partners are all equipped with professional transportation equipment and experience, and can provide reliable transportation services.
If you have any questions while using our products, or need further technical support and consultation, please feel free to contact us. Our professional team will wholeheartedly provide you with detailed and accurate answers to ensure that you have the best experience with the product. We promise that every inquiry you make will receive a timely and professional response to protect your rights and satisfaction.
Email Address:info@jiuybiotech.com
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