Cnidium Monnieri Extract

Cnidium Monnieri Extract is a natural active substance extracted from the dried mature fruit of Cnidium monnieri, a plant belonging to the Apiaceae family. It appears as a brownish-yellow to brownish-brown powder with a characteristic pungent and bitter taste. Cnidium monnieri is an annual herb that thrives in warm, humid environments but is also tolerant of cold and drought, showing wide adaptability. It is widely distributed in Eastern, Central, and Southern China.

Shaanxi Jiuyuan Biotech, with years of expertise in the botanical extract field, produces this extract through meticulous extraction and purification processes. This ensures that the various active components of Cnidium monnieri are preserved, resulting in a product with high biological activity and stability. It's also easy to store and transport, making it a premium natural botanical extract raw material widely applied in the pharmaceutical, health supplement, and cosmetic industries.

Cnidium Monnieri Extract is characterized by a complex phytochemical profile, with coumarins as the dominant functional components:

• Coumarins and Derivatives: Osthole, Imperatorin, Isopimpinellin, Xanthotoxin, Bergaptene, Isoimperatorin
• Volatile Oil Components: α-Pinene, Camphene, Bornyl isovalerate
• Other Constituents: β-Sitosterol, palmitic acid, and related lipophilic compounds

These compounds act through multi-target and synergistic pathways, forming the biochemical basis for the extract's functional properties observed in vitro and in traditional applications.

The following descriptions are based on mechanistic studies, traditional usage, and non-clinical research. They are not intended as medical claims.

1. Antimicrobial & Inflammation-Modulating Activity

Coumarins such as osthole have been shown to interfere with microbial cell membrane integrity and metabolic processes. In parallel, these compounds may modulate key inflammatory signaling pathways, contributing to the regulation of localized inflammatory responses.

2. Hormone-Related Biological Interaction

Certain constituents exhibit phytoestrogen-like receptor interactions in experimental models. These interactions are associated with endocrine-related signaling modulation, which explains the extract's historical use in formulations addressing hormone-related balance, particularly in traditional systems.

3. Antioxidant Activity

Phenolic and coumarin compounds contribute to free radical scavenging and inhibition of lipid peroxidation, supporting cellular oxidative balance and protection against oxidative stress at the biochemical level.

4. Immune Response Modulation

Non-clinical studies suggest that the extract may influence immune-related cellular activity, including macrophage and lymphocyte function, thereby supporting normal immune system responsiveness.

At Shaanxi Jiuyuan Bio, we deeply understand that high-quality Cnidium Monnieri Extract originates from meticulous attention to every detail. With a rigorous scientific attitude and advanced technological processes, we transform nature's gifts into a promise of health.

Raw Material Selection: Carefully select high-quality, impurity-free, and standard-compliant dried mature fruits of Cnidium monnieri as raw materials.
Washing and Drying: Thoroughly wash the selected raw materials to remove surface mud and impurities, then dry them to ensure the moisture content meets requirements.
Crushing: Crush the dried Cnidium monnieri fruits into a powder of appropriate particle size to increase the contact area between the raw material and the solvent, thereby improving extraction efficiency.
Extraction: Employ an ethanol reflux extraction method, mixing the crushed powder with an appropriate amount of ethanol solution and performing reflux extraction at a certain temperature to ensure the active components fully dissolve into the solvent.
Filtration: After extraction, remove residues by filtration to obtain the extract solution.
Concentration: Use a vacuum concentration method to evaporate the solvent from the extract solution, yielding a concentrated liquid.
Purification: Purify the concentrated liquid through methods like macroporous resin adsorption to remove impurities and increase the content of active components.
Drying: Spray-dry or vacuum freeze-dry the purified concentrated liquid to obtain Cnidium Monnieri Extract powder.
Packaging: Package the dried extract powder to ensure the product remains free from contamination during storage and transportation.

Pharmaceutical & TCM Formulations

Cnidium Monnieri Extract is commonly used as an ingredient in topical and localized formulations, such as ointments, suppositories, and external preparations, particularly within traditional Chinese medicine compound formulas. Its role is typically supportive, contributing antimicrobial and inflammation-regulating properties at the site of application.

Cosmetic & Personal Care

In cosmetic formulations, the extract is incorporated into:

Creams, lotions, and masks for antioxidant and skin-conditioning purposes

Cleansers, shampoos, and body washes, where it is valued for scalp comfort, cleansing support, and microbiome-friendly positioning

Its use aligns with botanical-based, functional cosmetic trends, especially in products targeting skin balance and protection.

Nutraceutical & Dietary Supplement Applications

As a botanical raw material, the extract may be formulated into capsules or tablets for general wellness support, particularly in products positioned around immune support or physiological balance. All applications must comply with applicable regional regulatory frameworks.

Agricultural & Plant Applications

Cnidium Monnieri Extract has been explored as a botanical input in agriculture, where it may support plant defense responses and physiological activity. It is used in experimental plant protection and growth-support formulations, aligning with interest in plant-derived agricultural solutions.

Compliance & Responsible Use Statement

This ingredient is intended for industrial, formulation, and research applications.
Health-related functions should be interpreted based on mechanistic data and traditional use, and not as claims for diagnosis, treatment, or prevention of disease. Regulatory status and permitted uses vary by market.

Established in 2012, Shaanxi Jiuyuan Biotechnology is a modern, high-tech enterprise specializing in the R&D, production, and sales of premium plant extracts and fruit & vegetable powders. Located in the Qinling Mountains region, renowned for its rich medicinal resources, we ensure quality from the source.

The company has constructed a state-of-the-art industrial plant spanning approximately 70,000 square meters, which includes a 2,000-square-meter Class 100,000 cleanroom facility. We have implemented 10 advanced production lines encompassing crude extraction, refined extraction, microencapsulation powder production, cosmetic manufacturing, and animal nutrition product manufacturing. With an annual production capacity exceeding 6,000 tons, the company has further optimized its production system and enhanced its comprehensive manufacturing capabilities to effectively address diverse market requirements.

Our state-of-the-art 70,000 sqm facility features advanced production lines and a Class 100,000 cleanroom, boasting an annual capacity of over 6,000 tons to meet diverse needs. We are committed to stringent quality control, ensuring full product traceability and holding numerous international certifications, including cGMP, EU/USDA Organic, ISO, FSSC 22000, HACCP, Kosher, Halal, and FDA registration.

With a strong focus on R&D and innovation, supported by collaborations with leading institutions and our new, well-equipped R&D and testing center (operational April 2025), we continuously develop high-quality, reliable ingredients.

Choose Jiuyuan for consistent quality, comprehensive certifications, and strong production capacity. Let's build a mutually successful partnership.

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Email: elsa.marketing@jiuybiotech.com

Phone No: +86 173 00897248

Professional Pre-sales and After-sales Service: We offer professional pre-sales and after-sales services, including product consultation, technical support, and logistics services. Our sales and customer service teams have extensive industry knowledge and experience, providing timely and professional assistance to clients.

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Express Under 100kg, 3- 5 days Door-to-door service easy to pick up the goods	By Sea Over 300 kg, Around 30 Days Port-to-port service professional clearance broker needed	By Air 100 kg- 1000 kg, 5- 7 days Airport-to-airport service professional clearance broker needed

Packages and Storage:

Storage: Keep in a cool, dry, and clean place. Protect from moisture and direct light.

Bulk Package: 25kg/drum.

Lead Time: 7 days after your order.

Shelf Life: 2 years.

Remark: Customized specifications can also be achieved.

References：

1. Mechanistic study of osthole in inflammation
Osthole inhibited TNF‑α, nitric oxide expression, and NF‑κB activation in macrophage models, indicating its role as a key anti-inflammatory constituent of Cnidium monnieri fruit extract. URL: https://pubs.acs.org/doi/abs/10.1021/jf102812t

2. Osthole against Tobacco Mosaic Virus (TMV)
Osthole extracted from Cnidium monnieri showed inhibitory and protective effects against TMV infection in experimental models.
URL: https://pubmed.ncbi.nlm.nih.gov/31878172/

3. Antifungal activity of coumarins from Cnidium monnieri
This study evaluated various coumarins for antifungal activity against plant pathogenic fungi, providing a mechanistic basis for antimicrobial applications. URL: https://pubmed.ncbi.nlm.nih.gov/34643056/

4. Comprehensive review of Cnidium monnieri
A review of the botany, traditional uses, chemical composition, and pharmacological properties of Cnidium monnieri, including major coumarin constituents. URL: https://pubmed.ncbi.nlm.nih.gov/26243582/

5. Pharmacology and pharmacokinetics of osthole: a review
A systematic review covering osthole's pharmacological actions, metabolism, and safety profile, providing current insights into this natural compound.
URL: https://pubmed.ncbi.nlm.nih.gov/39327653/

6. Osthole and imperatorin enhance neurotransmitter release
Experimental research shows that osthole and imperatorin can enhance glutamate release from nerve terminals, involving calcium channel-mediated signaling cascades. URL: https://pubmed.ncbi.nlm.nih.gov/18951936/

7. Enzymatic basis of coumarin biosynthesis in Cnidium monnieri
Reports on two methyltransferases catalyzing O-methylated coumarin biosynthesis in Cnidium monnieri, elucidating molecular pathways for coumarin production. URL: https://doi.org/10.1021/acs.jnatprod.2c00410

where to buy

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