Centella Asiatica Extract Powder

Centella Asiatica Extract Powder is a natural active ingredient extracted from the dried whole herb of Centella asiatica (L.) Urban, a plant belonging to the family Apiaceae (Umbelliferae). It possesses various biological activities and is widely used in cosmetics, pharmaceuticals, food, and other fields.

At Jiuyuan Biotech, every batch is HPLC-quantified for all four primary triterpenoid markers individually, with a defined ratio profile that reflects the natural composition of Centella asiatica aerial parts. That is the specification that serious formulators require - and the one we deliver.

• Source:

Centella asiatica is a perennial, creeping herbaceous plant widely distributed in tropical and subtropical regions. It has a long history of application in traditional medicine, commonly used for clearing heat and dampness, detoxifying and reducing swelling, and treating traumatic injuries.

• Various specifications, customizable：

Total Triterpenes 10%-90%;
Asiaticoside 10%-95%
Madecassoside 10%-95%;
Asiatic Acid 54~66%
36%~44% (Asiaticoside + Madecassoside)
56%~64% (Asiatic acid + Madecassoside)

Centella asiatica owes its pharmacological versatility to a quartet of triterpenoid saponins that work through overlapping but mechanistically distinct pathways.

The Four Primary Triterpenoids

• Asiaticoside

A triterpenoid saponin (glycoside form) that stimulates collagen type I and type III synthesis in dermal fibroblasts by upregulating TGF-β1 signaling. Asiaticoside also promotes angiogenesis in wound tissue - the formation of new blood vessels essential for tissue repair. It is the primary marker compound in most pharmacopoeial monographs for C. asiatica standardization.

• Madecassoside

The most potent anti-inflammatory triterpenoid in the C. asiatica profile. Madecassoside suppresses NF-κB pathway activation, reduces pro-inflammatory cytokine production (IL-1β, TNF-α, IL-6), and inhibits COX-2 expression in inflamed tissue. It also demonstrates significant antioxidant activity via Nrf2 pathway modulation. In skin applications, madecassoside is the compound most directly associated with the soothing and redness-reduction effects attributed to cica formulations.

• Asiatic Acid

The aglycone form of asiaticoside (post-hydrolysis of the sugar moiety). Asiatic acid demonstrates direct fibroblast-stimulating activity and has been shown to inhibit hypertrophic scar formation by modulating TGF-β/Smad signaling - a mechanism relevant to post-procedure scar management formulations. It also exhibits neuroprotective properties investigated in cognitive health research contexts.

• Madecassic Acid

The aglycone counterpart of madecassoside. Madecassic acid contributes to the anti-inflammatory and antioxidant profile of the extract and has demonstrated activity in collagen cross-linking support - relevant for skin firmness and elasticity applications.

Secondary Phytochemical Profile

These triterpenoids have diverse mechanisms of action, mainly demonstrated in the following aspects:

• Promotes Collagen Synthesis: Asiatic Acid and Asiaticoside stimulate the synthesis of Type I and Type III collagen, which helps repair damaged tissue, enhances skin elasticity, and firms the skin.
• Anti-inflammatory and Soothing: They can inhibit the release of inflammatory mediators (such as TNF-α, IL-8, etc.), thereby reducing skin redness, irritation, and inflammatory reactions, exerting a soothing effect.
• Wound Healing: By promoting the proliferation of fibroblasts and angiogenesis (the formation of new blood vessels), they accelerate tissue repair and the wound healing process following skin damage.
• Antioxidant: Possesses a certain ability to scavenge free radicals, protecting cells from oxidative damage.

• Raw Material Selection and Pre-treatment: Select high-quality Centella asiatica whole herb, clean, and dry it.
• Extraction: The effective components are usually dissolved out using solvents such as water or ethanol.
• Concentration: The extract is concentrated under reduced pressure to remove most of the solvent.
• Separation and Purification: Techniques like liquid-liquid extraction, silica gel column chromatography, etc., are used to separate and refine the target active components (e.g., Asiaticoside, Asiatic Acid).
• Drying: The purified product is spray-dried or vacuum-dried to produce the Centella Asiatica Extract powder.
• Quality Control: Testing for the content of active components (such as Asiaticoside content), microorganisms, and heavy metals to ensure product quality.

• Natural Botanical Extract, Gentle and Safe: Derived from natural herbs, it has good biocompatibility compared to some synthetic chemical components, is widely used in cosmetics, and has a high safety profile.
• "All-in-One" Skin Repair Agent: Centella Asiatica Extract combines multiple benefits-wound healing promotion, anti-inflammation, soothing, barrier repair, and antioxidant properties-making it one of the few plant extracts that comprehensively addresses skin damage and aging.
• Clear Efficacy, Scientific Validation: The pharmacological activity and mechanism of action of its core active components (triterpenoids) have been confirmed by extensive modern pharmacological and clinical research, with clear active components and action pathways.
• Industrial Production Potential: The extraction and preparation process is mature. Some patented processes can achieve fewer steps, lower costs, and solvent recycling, making them suitable for large-scale industrial production.

Grade Comparison: Choosing the Right Centella Asiatica Specification

Centella Asiatica vs. Competing Skin-Repair Botanicals

Key takeaway: No other commonly used skin-repair botanical matches centella asiatica's combination of RCT-validated wound healing activity, mechanistically characterized collagen stimulation, and anti-inflammatory potency. Its clinical evidence base is the deepest in the botanical skin-repair category.

At JIUYUAN BIOTECH, product quality is our top priority. We achieve this through a comprehensive and robust quality control system that meticulously manages every stage of production with scientific rigor. By strictly adhering to operational protocols, we ensure the traceability of every batch of our products.

Shaanxi Jiuyuan Bio currently holds numerous domestic and international industry certifications and qualifications, ensuring our operations in production, R&D, and sales consistently meet demanding standards. Our key certifications include:

With our advanced production facilities, a state-of-the-art testing and control center, and our complete quality control system, we consistently ensure the safety and stability of our products and services.

Company Profile

Founded: 2012, based in Xi'an at the northern foot of the Qinling Mountains.

Business Scope: A high-tech enterprise specializing in the R&D, production, and sales of plant extracts and fruit and vegetable powders.

Mission: Committed to providing high-quality products and services to the health food, food, and cosmetics industries, to lead China's plant extract sector.

Core Strengths

R&D and Quality Control:

Equipped with advanced testing equipment, including HPLC and UV spectrometers, for precise analysis of active ingredient content and purity.

A professional testing team provides detailed product analysis reports to ensure quality and safety.
Supply Chain Management:

Maintains long-term, stable partnerships with local farmers.

Utilizes a contract farming and procurement model to guarantee a consistent supply of high-quality raw materials.
Production and Warehousing:

Boasts comprehensive production facilities with advanced equipment and automated lines to meet large-volume demands.

Our robust warehousing system ensures optimal storage conditions, maintaining product quality and stability.

Express Under 100kg, 3-5Days Door-to-door service easy to pick up the goods	By Sea Over300kg, Around 30 Days Port-to-port service professional clearance broker needed	By Air 100kg-1000kg, 5-7Days Airport-to-airport service professional clearance broker needed

We offer three standard packaging formats, each designed around a specific order volume and transit risk profile:

The centella asiatica extract market has expanded rapidly alongside the "cica" skincare trend - and with that expansion has come a proliferation of poorly characterized, inconsistently standardized products. Here is what experienced procurement professionals verify before committing to a supplier:

1. Demand Four-Marker HPLC Data, Not "Total Saponins"

The single most important quality checkpoint for centella asiatica extract is individual HPLC quantification of all four primary triterpenoids: asiaticoside, madecassoside, asiatic acid, and madecassic acid. A "total saponins" figure derived from colorimetric assay (e.g., vanillin-sulfuric acid method) cannot distinguish between these compounds and cannot verify the ratio profile. Any supplier who cannot provide four-marker HPLC data is not operating at a professional cosmeceutical ingredient standard.

2. Verify Botanical Identity by TLC Fingerprint

Centella asiatica is subject to adulteration with related Hydrocotyle species, which share similar morphology but have a different triterpenoid profile. TLC fingerprint comparison against an authenticated reference standard is the minimum botanical identity verification requirement for a reputable supplier.

3. Scrutinize the Heavy Metals Panel

Centella asiatica is a bioaccumulator of heavy metals from contaminated growing soils - particularly lead and cadmium. ICP-MS testing covering Pb, As, Cd, Hg, and Cr is non-negotiable. Request batch-specific ICP-MS data, not a generic specification limit statement.

4. Confirm Pesticide Residue Coverage

C. asiatica cultivation in tropical regions frequently involves pesticide use. EU MRL-compliant pesticide residue screening (GC-MS/LC-MS/MS, 200+ compound panel) is essential for European cosmetic and supplement market supply. Do not accept a "pesticide-free" declaration without supporting analytical data.

5. Clarify the Extraction Solvent System

Ethanol extraction is the preferred method for cosmeceutical and nutraceutical grades. Methanol extraction - used by some lower-cost producers - introduces residual solvent concerns that complicate EU cosmetic ingredient compliance. Confirm the extraction solvent and request ICH Q3C-compliant residual solvent data.

6. Request a Pre-Shipment Sample for Each New Batch

Centella asiatica extract can vary significantly between harvest seasons and growing regions. Even with a trusted supplier, batch-to-batch verification against your in-house specification is good procurement practice - particularly for high-potency grades used in precision-dosed formulations.

Q1: What is the difference between asiaticoside and madecassoside, and why does the ratio matter? Asiaticoside and madecassoside are both triterpenoid saponins from Centella asiatica, but they have distinct primary activities. Asiaticoside is the dominant collagen-stimulating compound, acting via TGF-β1 upregulation in dermal fibroblasts. Madecassoside is the primary anti-inflammatory compound, acting via NF-κB suppression and COX-2 inhibition. A centella asiatica extract with high asiaticoside but low madecassoside will perform differently from a balanced four-marker extract in a soothing or anti-redness application. The ratio matters because different formulation targets require different triterpenoid emphasis. Our four-marker HPLC specification ensures you know exactly what ratio you are buying.

Q2: Is centella asiatica extract powder safe for use in cosmetic formulations? Yes. Centella asiatica extract has an extensive safety record in both topical and oral applications. It is listed in the EU Cosmetics Ingredient Database (CosIng) and is widely used in EU-marketed cosmetic products. Topical application of standardized centella asiatica extracts in clinical studies has shown no significant adverse reactions at typical use concentrations (0.1–2% in finished formulas). As with all active botanical extracts, patch testing is recommended for sensitive skin applications.

Q3: What use levels are recommended for centella asiatica extract in topical cosmetic formulas? Typical use levels depend on the extract grade and application target. For 10% grade: 1–5% in finished formula. For 40% grade: 0.5–2%. For 70% grade: 0.1–0.5%. For 90% grade: 0.05–0.2%. These ranges are formulation reference figures based on published cosmetic applications. Your formulation team should optimize use levels based on in-house efficacy and stability testing.

Q4: Can centella asiatica extract powder be used in oral dietary supplement formulations? Yes. Centella asiatica has a long history of oral use in Ayurvedic and traditional Chinese medicine, and standardized extracts are widely used in dietary supplements targeting cognitive support, vascular health, and venous insufficiency. For oral applications, our 10% and 40% grades are most commonly specified. Oral safety has been documented in clinical studies at doses up to 1,000 mg/day of standardized extract for periods of up to 8 weeks.

Q5: How does centella asiatica extract support wound healing at the cellular level? The wound healing activity of centella asiatica extract operates through several converging mechanisms. Asiaticoside stimulates fibroblast proliferation and migration into the wound bed, upregulates collagen type I and III synthesis via TGF-β1 signaling, and promotes angiogenesis - new blood vessel formation essential for tissue perfusion during repair. Madecassoside simultaneously suppresses the inflammatory phase of wound healing, preventing excessive inflammation that delays closure. Asiatic acid modulates TGF-β/Smad signaling to reduce hypertrophic scar formation during the remodeling phase. These mechanisms have been confirmed in multiple clinical trials.

Q6: What is the difference between TECA (Titrated Extract of Centella Asiatica) and standard centella asiatica extract? TECA is a specific, historically defined formulation of centella asiatica extract standardized to a defined ratio of 40% asiaticoside, 29–30% asiatic acid, and 29–30% madecassic acid - originally developed by the French pharmaceutical company SANOFI and used in the wound healing drug Madecassol. Standard centella asiatica extract refers to any extract standardized to total triterpenoid content without the specific TECA ratio requirement. Our 40% and 70% grades can be produced to TECA-equivalent ratios upon request for customers targeting pharmaceutical-adjacent applications.

Q7: Does centella asiatica extract have any known interactions or contraindications relevant to supplement formulations? At typical dietary supplement doses, centella asiatica extract has a favorable safety profile. Rare cases of hepatotoxicity have been reported in the literature at very high doses or with prolonged use of non-standardized preparations - a finding that underscores the importance of using properly standardized, quality-controlled extracts rather than crude herbal preparations. Formulators should include appropriate dosage guidance and consult current regulatory guidelines for their target market when developing oral supplement products.

Q8: What documentation is required for importing centella asiatica extract powder into the US or EU? For US import: COA, MSDS, FDA Food Facility Registration number, country of origin, allergen declaration, and botanical identity documentation. For EU cosmetic ingredient import: COA, MSDS, CosIng compliance documentation, allergen declaration per Regulation 1169/2011 (if food/supplement use), pesticide residue compliance per EU MRLs, and REACH compliance documentation. For EU supplement import: Novel Food status confirmation (centella asiatica is not classified as novel food under EU 2015/2283 for traditional use applications). We provide a complete regulatory documentation package with every shipment.

Jiuyuan Biotech manufactures and supplies centella asiatica extract powder to cosmeceutical brands, dietary supplement manufacturers, pharmaceutical formulators, and private label developers across North America, Europe, Australia, and Southeast Asia. With in-house four-marker HPLC quantification, EU MRL-compliant pesticide residue screening, and a complete regulatory documentation suite, we deliver the technical precision that centella asiatica formulation demands.

Whether you need a 10% food-grade powder for an oral wellness product or a 90% ultra-pure concentrate for a precision-dosed wound care preparation, our technical team is equipped to match your specification requirements.

Contact us for batch-specific COA, grade-specific pricing, and complimentary samples.

🌐 www.jiuyuanbio.com 

Email: info@jiuyuanbio.com

📞 +86 029 88215052

Source your next batch of centella asiatica extract powder from a manufacturer who can back every specification with data.