Lophatherum Powder

Lophatherum Powder (also known as Dan Zhu Ye Powder) is a natural plant powder produced by finely milling the dried stems and leaves of Lophatherum gracile Brongn., a grass family plant widely used in Traditional Chinese Medicine (TCM) and functional food applications.

Unlike extracts, Lophatherum Powder is a non-extracted, full-spectrum raw material, retaining the plant's native flavonoids, polysaccharides, amino acids, and dietary fiber. It is suitable for manufacturers seeking a clean-label, minimally processed botanical ingredient. The product appears as a light yellow to brown fine powder with the characteristic herbal aroma of Lophatherum gracile. It disperses well in water-based formulations and is suitable for direct blending or further processing.

Source: Stems and leaves of Lophatherum gracile Brongn., cultivated and harvested in the southern regions of China. The plant is traditionally consumed as both a medicinal herb and herbal tea ingredient.

• Whole-Herb Powder: Non-extracted, full-spectrum botanical ingredient
• Clean Label: No solvents, no additives
• Medicinal & Edible Heritage: Long history of safe traditional use
• Versatile Applications: Suitable for food, supplement, and cosmetic formulations
• Stable Supply: Contract farming ensures consistent quality and availability

Lophatherum gracile contains one of the more structurally diverse flavonoid profiles among commonly used TCM herbs. A 2024 comprehensive review published in Chinese Herbal Medicines (Yao et al., PMC12009075) identified 44 flavonoids and 16 phenolic acids from Lophatheri Herba, with flavonoid glycosides and hydroxybenzoic acids as the dominant structural classes in each category respectively.

Flavonoids - Primary Bioactive Fraction

Orientin (luteolin-8-C-glucoside, CAS 28957-04-2) The principal flavonoid C-glycoside in Lophatheri Herba. Orientin has been extensively studied for its anti-inflammatory activity - specifically its capacity to suppress NF-κB pathway activation and reduce pro-inflammatory cytokine expression (TNF-α, IL-6, IL-1β) in macrophage models. A 2025 review in Molecules documented orientin's neuroprotective effects via modulation of the GSK3β/NF-κB and Nrf2/HO-1 pathways, suggesting potential utility in neuroinflammation-related formulations.

Isoorientin (luteolin-6-C-glucoside, CAS 4261-42-1) The C-6 isomer of orientin. Isoorientin has demonstrated cardioprotective activity in preclinical models - specifically attenuating myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic mechanisms. The 2024 Chinese Herbal Medicines review identifies isoorientin as one of the most pharmacologically active monomers in Lophatheri Herba, alongside luteolin and luteolin-7-O-β-D-glucoside.

Vitexin (apigenin-8-C-glucoside, CAS 3681-93-4) A flavone C-glycoside with documented antioxidant activity in DPPH and ABTS assay models. Vitexin is present in Lophatheri Herba alongside its isomer isovitexin (apigenin-6-C-glucoside).

Luteolin (CAS 491-70-3) The aglycone of orientin and isoorientin. Luteolin has one of the most extensively characterized anti-inflammatory profiles of any dietary flavonoid - documented inhibition of COX-2, LOX, and NF-κB in multiple preclinical models. Present in Lophatheri Herba both as the free aglycone and as glycosides (luteolin-7-O-β-D-glucoside).

Apigenin (CAS 520-36-5) A flavone with documented anxiolytic, anti-inflammatory, and mild sedative activity in preclinical models. Its presence in Lophatheri Herba contributes to the herb's traditional use for calming febrile agitation and restlessness.

Phenolic Acids - Secondary Bioactive Fraction

Lophatheri Herba contains 16 identified phenolic acids, with hydroxybenzoic acid derivatives as the dominant structural class:

• p-Hydroxybenzoic acid - antioxidant; antimicrobial activity in vitro
• Vanillic acid - antioxidant; documented anti-inflammatory activity
• Syringic acid - antioxidant; hepatoprotective activity in preclinical models
• Ferulic acid - hydroxycinnamic acid; broad antioxidant and anti-inflammatory activity; documented in L. gracile by HPLC profiling
• Caffeic acid - antioxidant; COX inhibition in vitro

Other Constituents

• Triterpenoids - including arundoin and cylindrin; contribute to the anti-inflammatory profile
• Amino acids - including γ-aminobutyric acid (GABA); potentially relevant to the herb's calming/sedative traditional use
• Polysaccharides - heteropolysaccharides with antioxidant and immunomodulatory activity in preclinical models

Compound Summary Table

Based on traditional usage and modern nutritional research, Lophatherum Powder is associated with the following properties:

• Antioxidant Support: Natural flavonoids help neutralize free radicals and reduce oxidative stress
• Soothing & Cooling Properties: Traditionally used to clear internal heat in TCM formulations
• Mild Antibacterial Potential: Certain flavonoids exhibit inhibitory activity against common microorganisms
• Diuretic Support: Traditionally associated with promoting urination and fluid balance
• General Wellness Support: Suitable for daily wellness and functional food applications

These statements are based on traditional use and ingredient characteristics and are not intended as medical claims.

Raw Material Selection: Harvesting qualified stems and leaves of Lophatherum gracile

Cleaning & Drying: Removal of impurities followed by low-temperature drying

Grinding: Fine milling into powder

Sieving: Particle size control

Quality Inspection: Physical, chemical, and microbiological testing

Packaging: Food-grade packaging under controlled conditions

The convergence of anti-inflammatory, antipyretic, diuretic, cardioprotective, and calming activities in a single botanical with clean food-grade regulatory status makes Lophatherum gracile unusually versatile across supplement and functional food categories.

Formulation Note on Dual-Category Regulatory Status: In China, Lophatheri Herba is listed in both the Chinese Pharmacopoeia 2020 and the national list of substances with medicinal and food homologous status . This dual classification supports its use in both registered food products and dietary supplements without requiring novel food authorization - a significant regulatory advantage for brands building in the Asian wellness and functional food categories. For EU and US markets, positioning as a traditional herbal ingredient with documented historical use is the appropriate regulatory pathway.

At Jiuyuan Biology, quality and safety are managed through a comprehensive quality control system covering raw material sourcing, processing, testing, and traceability. Each batch of Lophatherum Powder is produced following standardized procedures and documented quality records.

Shaanxi Jiuyuan Bio holds multiple domestic and international certifications supporting compliance in production, R&D, and global trade. Documentation such as COA, MSDS, and specification sheets are available upon request.

With our advanced production facilities, a state-of-the-art testing and control center, and our complete quality control system, we consistently ensure the safety and stability of our products and services.

Lophatherum Powder vs. Competing Cooling/Anti-inflammatory Botanicals

One of the most common formulation questions for this ingredient is: why use Lophatherum gracile when there are better-known anti-inflammatory botanicals available? The answer is not that it outperforms every competitor on every metric - it is that it occupies a distinct niche that none of the alternatives fill.

Whole Herb Powder vs. Standardized Extract vs. Ratio Extract

Founded: 2012, based in Xi'an at the northern foot of the Qinling Mountains.

Business Scope: A high-tech enterprise specializing in the R&D, production, and sales of plant extracts and fruit and vegetable powders.

Mission: Committed to providing high-quality products and services to the health food, food, and cosmetics industries, to lead China's plant extract sector.

R&D and Quality Control:

Equipped with advanced testing equipment, including HPLC and UV spectrometers, for precise analysis of active ingredient content and purity.

A professional testing team provides detailed product analysis reports to ensure quality and safety.
Supply Chain Management:

Maintains long-term, stable partnerships with local farmers.

Utilizes a contract farming and procurement model to guarantee a consistent supply of high-quality raw materials.
Production and Warehousing:

Boasts comprehensive production facilities with advanced equipment and automated lines to meet large-volume demands.

Our robust warehousing system ensures optimal storage conditions, maintaining product quality and stability.

Express Under 100kg, 3-5Days Door-to-door service easy to pick up the goods	By Sea Over300kg, Around 30 Days Port-to-port service professional clearance broker needed	By Air 100kg-1000kg, 5-7Days Airport-to-airport service professional clearance broker needed

Q1: What is the difference between Lophatherum gracile and bamboo leaf? Are they the same ingredient?

They are related but distinct botanical ingredients. Lophatherum gracile (Lophatheri Herba, Danzhuye) and true bamboo (Phyllostachys spp., Zhuye) are both members of the Poaceae (grass) family, but they are different genera with different phytochemical profiles and different traditional indications. Lophatheri Herba is standardized in the Chinese Pharmacopoeia 2020 as a specific botanical drug derived from Lophatherum gracile Brongn. only. True bamboo leaf (Phyllostachys spp.) has a different flavonoid profile - higher in chlorogenic acid and different C-glycoside ratios - and is used in different applications. Adulteration of Lophatheri Herba with Phyllostachys leaf is a known quality issue in the raw herb market. We use TLC fingerprinting per Chinese Pharmacopoeia 2020 to verify botanical identity on every incoming lot.

Q2: What are the primary active compounds in Lophatherum Powder, and how are they measured?

The primary active compounds are flavonoid C-glycosides - principally orientin (luteolin-8-C-glucoside) and isoorientin (luteolin-6-C-glucoside) - along with flavone aglycones including luteolin and apigenin, and a phenolic acid fraction. A 2024 comprehensive review in Chinese Herbal Medicines (Yao et al.) identified 44 flavonoids and 16 phenolic acids in Lophatheri Herba, with flavonoid glycosides as the dominant structural class. Total flavonoid content is measured by UV spectrophotometry (rutin equivalent). Compound-specific quantification of orientin and isoorientin is available by HPLC on request.

Q3: What are the documented pharmacological activities of Lophatherum gracile extract?

Modern pharmacological research has documented the following activities in preclinical models: anti-inflammatory (NF-κB pathway suppression by orientin and isoorientin), antipyretic, diuretic, cardioprotective (myocardial protection by isoorientin in ischemia-reperfusion models), hepatoprotective, and hypoglycaemic. Orientin has additionally been studied for neuroprotective activity via GSK3β/NF-κB and Nrf2/HO-1 pathway modulation. All activities are ingredient-level characteristics documented in preclinical research - not clinical outcomes, and not the basis for disease treatment claims.

Q4: Is Lophatherum Powder suitable for use in EU-regulated food supplements?

Lophatherum gracile is not currently listed in the EFSA Compendium of Botanicals with safety concerns, and it can be positioned in EU food supplements as a traditional herbal ingredient based on its documented history of use in Chinese medicine since at least the Tang Dynasty (659 CE). It is not subject to Novel Food authorization under EU Regulation 2015/2283 based on this history of use, though we recommend obtaining a formal legal opinion for your specific target market and product format. We provide a full regulatory documentation package including Chinese Pharmacopoeia 2020 compliance statement, botanical identity documentation, and historical use references to support your EU regulatory filing.

Q5: What is the recommended serving size for supplement formulations?

Serving size depends on the grade and application. For a standardized extract (≥10% total flavonoids), typical supplement serving sizes in published formulations range from 200–600 mg per serving. For whole herb powder, 1–3 g per serving is more typical, consistent with traditional decoction equivalents. We recommend working with your formulation team to select the appropriate grade and serving size for your target application. We can provide the relevant published references and our technical team can advise on formulation compatibility.

Q6: Can you supply Lophatherum Powder with a specific orientin content verified by HPLC?

Yes. Our HPLC-standardized grade specifies orientin content (≥1% by HPLC) in addition to total flavonoid content by UV. We provide the HPLC chromatogram alongside the COA for this grade. For buyers requiring a specific orientin-to-isoorientin ratio or a defined luteolin content, we can develop a custom specification - contact us with your target parameters and we will advise on feasibility and pricing.

Q7: Does Lophatherum gracile have any known safety concerns or contraindications relevant to supplement formulations?

Lophatheri Herba has a well-documented safety profile based on centuries of use in Chinese medicine and its classification as a medicinal-food homologous substance in China. No significant toxicity has been reported at typical dietary or supplement doses in the published literature. As with any botanical ingredient, we recommend that finished product brands include appropriate advisory language for pregnant or breastfeeding women and individuals taking prescription medications, and consult regulatory counsel for their specific target market. We provide a complete safety documentation package including MSDS/SDS and allergen declaration on request.

Q8: What is your supply capacity, and can you support long-term contract supply?

Our production facility covers 70,000 m² with multiple dedicated extraction and purification lines. Lophatherum gracile raw material is widely available in southern and southwestern China, with established cultivation in Zhejiang, Hunan, and Sichuan provinces. We support long-term supply agreements with fixed pricing, reserved production capacity, and quarterly quality audits. Annual supply capacity for Lophatheri Herba-based products is scalable to several hundred metric tons of finished extract. Contact us to discuss your volume requirements and we will provide a supply capacity confirmation and indicative pricing within 24 hours.

The global market for TCM-derived botanical ingredients is expanding rapidly - driven by growing consumer demand for traditional wellness narratives, clean-label ingredients, and botanicals with multi-mechanism activity profiles. Lophatherum gracile sits at the intersection of all three trends: a 1,300-year documented history of use, a well-characterized flavonoid profile with modern preclinical validation, and medicinal-food homologous regulatory status that opens both supplement and functional food pathways simultaneously.

Jiuyuan Biotech supplies Lophatherum Powder standardized to total flavonoids by UV and orientin by HPLC, produced from authenticated Lophatherum gracile raw material, screened against a 539-compound pesticide panel, and supported by a complete regulatory documentation package for US and EU market compliance.

Our facility is FDA-registered, cGMP-certified, and FSSC 22000-audited. Samples start at 10 g. MOQ is 1 kg.

📧 Contact us: info@jiuybiotech.com 📞 Phone: +86 029 88215052 🌐 Website: www.jiuyuanbio.com

Send us your target specification, application, target market, and annual volume estimate - and we will respond with a sample offer, COA, TLC fingerprint report, and competitive pricing within 24 hours.