Urolithin A Powder

In the healthy aging market, brands are moving beyond generic antioxidants and looking for ingredients with a clearer biological narrative, stronger scientific visibility, and better formulation precision. Urolithin A Powder fits this shift: it is a well-studied postbiotic metabolite associated with mitochondrial quality control, cellular renewal pathways, and next-generation longevity nutrition.

Jiuyuan Biotech supplies Urolithin A as a refined powder ingredient for B2B customers developing capsules, tablets, powder blends, and premium healthy aging products. Our focus is practical: reliable specifications, transparent testing, responsive documentation, and commercial-scale supply support.

Urolithin A Powder is a postbiotic metabolite derived from the microbial transformation of ellagitannins, polyphenols abundant in fruits like pomegranates, within the gut. Its production is dependent on an individual's gut microbiota composition. This compound exhibits significant biological activities, acting as a potent antioxidant by scavenging free radicals and demonstrating anti-inflammatory effects through modulation of key inflammatory pathways.

● Molecular Structure
Molecular Formula: C13H8O4
Molecular Weight: 228.20 g/mol

● Appearance
Yellow to light yellow solid powder under standard ambient temperature and pressure.

● Solubility
Soluble in strongly polar organic solvents such as dimethyl sulfoxide (DMSO) and N,N-dimethylformamide (DMF).
Exhibits poor solubility in low-polarity solvents like petroleum ether and diethyl ether.
Demonstrates very limited solubility in water.

● Stability
The powder form is stable for 2 years when stored at -20°C. Solutions can be stored for 1 year at -80°C.

● Biological Activity
Characterized by anti-inflammatory, anti-proliferative, and antioxidant properties.
Capable of inducing autophagy and apoptosis, inhibiting cell cycle progression, and suppressing DNA synthesis.

Urolithin A as the Defined Active

Unlike broad-spectrum botanical extracts, Urolithin A is a defined compound with a clear chemical identity. This gives formulators and QA teams a major advantage because specification, testing, and label positioning can be more precise.

Because Urolithin A is a defined active, buyers should pay close attention to assay method, reference standard, impurity profile, and residual solvent control. These details often separate a serious ingredient supplier from a low-cost listing.

The fundamental process for the large-scale production of Urolithin A Powder from pomegranate peel extract primarily involves the following steps:

(1) Raw Material Preparation: Selection of pomegranate peels rich in ellagitannins as the starting material.
(2) Extraction:
The pomegranate peels are pulverized, and an appropriate solvent (e.g., ethanol, etc.) is added for reflux extraction under heating.
During the extraction process, the solvent dissolves the active components, including ellagitannins, from the pomegranate peel.
(3) Filtration and Concentration:
Upon completion of the extraction, the mixture is filtered to remove solid impurities.
The filtrate is then concentrated to remove the majority of the solvent, yielding a concentrated extract rich in ellagitannins.
(4) Microbial Fermentation:
The concentrated extract is inoculated with specific gut microbiota strains.
Fermentation is carried out under suitable conditions (e.g., temperature, pH) to facilitate the bioconversion of ellagitannins into Urolithin A by the microorganisms.
(5) Separation and Purification:
Following fermentation, the fermentation broth is processed through methods such as centrifugation and filtration to remove microbial cells and solid residues. Chromatographic techniques (e.g., silica gel column chromatography) and other suitable purification methods are employed for the further purification of Urolithin A.
(6) Drying and Milling:
The purified Urolithin A solution undergoes a drying process to obtain a solid powder.
The dried powder is then milled to achieve the desired particle size.
(7) Quality Control and Packaging:
The final product undergoes rigorous quality testing, including purity analysis (e.g., HPLC), heavy metal content determination, and microbiological testing. Upon passing quality control, the product is packaged, with common packaging specifications including 1 kg/bag and 25 kg/drum.

Urolithin A Powder is a compound exhibiting diverse bioactivities, leading to its exploration across several domains:

1. Health and Nutritional Supplements:

Healthy Aging Support: Urolithin A has demonstrated the ability to induce mitophagy, the selective degradation of damaged mitochondria, thereby improving mitochondrial function. This mechanism is theorized to contribute to the slowing of age-related cellular decline and is being investigated for its potential in healthy aging supplements.
Muscle Health: Preclinical studies and emerging human research suggest that Urolithin A may enhance muscle endurance and counteract age-related muscle decline (sarcopenia) by improving mitochondrial bioenergetics. It is being explored as an ingredient in sports and healthy aging nutritional supplements.
Antioxidant and Anti-inflammatory Support: As a potent antioxidant capable of scavenging free radicals and modulating inflammatory pathways, Urolithin A is being considered for its potential to support overall well-being by mitigating oxidative stress and inflammation.

2. Disease Prevention and Therapeutics (Under Investigation):

Oncology Research: In vitro and in vivo studies indicate that Urolithin A exhibits anti-proliferative effects and can induce apoptosis in various cancer cell lines (e.g., colorectal and hepatic). It is being investigated as a potential agent in cancer prevention and as an adjunct to conventional therapies, although human clinical trials are needed to confirm these findings.
Neurodegenerative Disease Research: Preclinical research suggests that Urolithin A may offer neuroprotective effects in models of Alzheimer's and Parkinson's diseases by improving mitochondrial function and reducing oxidative stress and neuroinflammation. Further research is necessary to determine its efficacy in human neurodegenerative conditions.
Metabolic Health Research: Some studies suggest a role for Urolithin A in modulating metabolic pathways, potentially impacting conditions like obesity and type 2 diabetes. These effects require further investigation in human clinical trials.

3. Cosmeceuticals:

Anti-Aging Skincare: Based on its antioxidant and anti-inflammatory properties, Urolithin A is being explored for its potential to reduce signs of skin aging, such as wrinkles and loss of elasticity, by protecting against oxidative damage and inflammation.
Skin Repair Support: Urolithin A may promote skin cell turnover and repair mechanisms, suggesting potential applications in formulations for damaged skin.

4. Food and Beverage:

Functional Foods: Urolithin A is being considered as a potential ingredient in functional foods, such as nutritional bars and beverages, to offer antioxidant and healthy aging benefits.
Nutraceuticals: Urolithin A powder is utilized as a primary ingredient in the formulation of nutraceutical products, including capsules and tablets, marketed for its health-promoting properties.

5. Research and Experimentation:

Biological Research Tool: Urolithin A powder is commonly used in biomedical research as a tool to study mitochondrial function, apoptosis, autophagy, and antioxidant mechanisms in cellular and animal models.
Drug Discovery: Due to its diverse bioactivities, Urolithin A is also being investigated in drug discovery research to explore its therapeutic potential across various diseases.

6. Other Applications:

Animal Health: Urolithin A is being explored for its potential to improve mitochondrial health and overall physiological function in animals.
Plant Protection (Potential): Given that its precursors (ellagitannins) have protective roles in plants, Urolithin A's potential applications in plant protection are being considered.

Conclusion:

Urolithin A powder exhibits a wide range of promising bioactivities, leading to diverse potential applications. However, it is crucial to acknowledge that the efficacy of Urolithin A may vary among individuals, and further research, particularly well-designed human clinical trials, is necessary to fully validate its benefits across these applications. Individuals should consult with healthcare professionals for personalized advice regarding its use.

The healthy aging category is crowded. The table below helps formulators understand how Urolithin A differs from other popular ingredients.

Urolithin A stands out because it gives brands a precise, modern, and research-relevant angle in mitochondrial wellness, while avoiding the overly generic feel of many antioxidant ingredients.

Established in 2012, Shaanxi Jiuyuan Biotechnology is a modern, high-tech enterprise specializing in the R&D, production, and sales of premium plant extracts and fruit & vegetable powders. Located in the Qinling Mountains region, renowned for its rich medicinal resources, we ensure quality from the source.

Our state-of-the-art 70,000 sqm facility features advanced production lines and a Class 100,000 cleanroom, boasting an annual capacity of over 6,000 tons to meet diverse needs. We are committed to stringent quality control, ensuring full product traceability and holding numerous international certifications, including cGMP, EU/USDA Organic, ISO, FSSC 22000, HACCP, Kosher, Halal, and FDA registration.

With a strong focus on R&D and innovation, supported by collaborations with leading institutions and our new, well-equipped R&D and testing center (operational April 2025), we continuously develop high-quality, reliable ingredients.

Choose Jiuyuan for consistent quality, comprehensive certifications, and strong production capacity. Let's build a mutually successful partnership. 

We cooperate with multiple professional logistics companies to provide efficient and secure logistics services.
We ensure the timely and complete delivery of products to customers, regardless of their location.
We offer a variety of logistics options for customers to choose from, including express delivery, air freight, and sea freight.

Storage: Keep in a cool, dry, and clean place, protect from moisture and direct light.
Bulk Package: 25kg/drum.
Lead Time: 7 days after your order.
Shelf Life: 2 years.
Remark: Customized specifications can also be achieved.

1. What is Urolithin A?

Urolithin A is a metabolite associated with the transformation of ellagitannins and ellagic acid by gut microbiota. It is studied for its relationship with mitochondrial quality control, cellular health, and healthy aging.

2. What is Urolithin A Powder used for?

It is commonly used as a raw material in dietary supplements, healthy aging formulas, mitochondrial wellness products, capsules, tablets, and premium functional nutrition products.

3. Is Urolithin A the same as pomegranate extract?

No. Pomegranate extract contains polyphenols such as ellagitannins and ellagic acid. Urolithin A is a defined compound that may be produced from these precursors by gut microbiota, depending on individual microbiome composition.

4. What purity can you supply?

Purity and assay specifications can be discussed according to customer requirements and application needs. Final values should be confirmed in the specification sheet and batch COA.

5. Can you provide a sample?

Yes. Samples are typically available for formulation evaluation, quality review, and internal testing before bulk purchase.

6. What documents are available?

Common documents include COA, specification sheet, MSDS/SDS, production flow chart, allergen statement, GMO statement, BSE/TSE statement, residual solvent information, heavy metal data, microbiological data, and export documents.

7. Is this ingredient suitable for capsules and tablets?

Yes. Urolithin A is well suited for capsule and tablet applications. Formulators should evaluate flowability, excipient compatibility, blend uniformity, and finished-product stability.

8. Can finished products make anti-aging claims?

Claim language depends on the target market, dosage, formulation, and substantiation. Responsible positioning around healthy aging, mitochondrial wellness, and cellular health is recommended. Disease treatment or drug-like claims should be avoided unless authorized by the relevant regulatory authority.

Jiuyuan Biotech supplies Urolithin A Powder to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

Request: Sample (500g–1kg) | Bulk Quote | CoA & Spec Sheet | Custom Carrier Ratio

Standard response time: within 1 business day. Please include your target application and annual volume estimate for the most relevant technical recommendation.