Cordyceps Militaris Extract Powder

Our Cordyceps Militaris Extract Powder is grown on our own USDA- and EU-certified farm in Shaanxi, harvested on day 70 when adenosine peaks at 0.25%, and extracted at 40-45°C with pure water and multi-stage membranes. The gentle process keeps ≥98% of actives intact and yields a powder standardised to ≥10~50% polysaccharides. Every lot is accompanied by a detailed COA, assuring purity, safety, and repeatable potency for high-end nutraceutical, food, and cosmetic applications.

Key Advantages:

Leaf Certified Organic & Sustainable: USDA & EU Certified, meeting the highest standards for clean-label products. 
Chart Standardized High Potency: Guaranteed 10~50% Polysaccharides and high Adenosine content for consistent efficacy. 
Shield Full Traceability & Safety: From our owned organic cultivation base to your facility, with comprehensive COA and 3rd-party testing. 
Gear B2B Customization Support: Flexible ratios, powder forms, and OEM/ODM solutions tailored to your specific formulation needs. 

Specification Table

• Product Name: Organic Cordyceps Militaris Extract Powder
• Botanical Source: Cordyceps militaris
• Part Used: Fruit body
• Extraction Ratio: 10：1
• Active Components: Polysaccharides ≥10~50%, or β-glucan 10%~30%, or Adenosine ≥0.1%
• Appearance: Fine Orange-Brown Powder
• Solubility: Water-Soluble
• Sieve Analysis: 100% through 80 mesh
• Loss on Drying: <5%
• Heavy Metals: Meet USP/EP Standards
• Microbiology: Total Plate Count, Yeast & Mold, etc., within limits.
• Quality Documents: COA (Certificate of Analysis), MSDS (Material Safety Data Sheet).

Certification Badges:

1. Nutraceuticals & Dietary Supplements

A. Immune Support

Human Equivalent Dose (HED) Conversion: Mouse 400 mg/kg → Human 2 g/day (based on 60 kg body weight, FDA HED factor 0.162). Mechanism of Action: Increases Granzyme B and Perforin expression, enhancing NK cell cytotoxic activity by 32% (p<0.01, C57BL/6, 14 days). Preclinical Safety Window: NOAEL 5 g/kg·d (rat, 90 days), with a safety margin of >100.

B. Endurance & Anti-Fatigue

Clinical Trial: Double-blind, placebo-controlled, crossover design (n=24, M/F split, age 28±4 y)

VO₂max increased by 7.8% (46.1→49.7 mL/kg/min, p=0.018).

Blood lactate decreased by 18% (12.1→9.9 mmol/L, p=0.026).

Time to exhaustion increased by 13% (treadmill).

Recommended Dosage: 500 mg/capsule, 2 capsules per day. Efficacy observed within 4 weeks. Can be combined with 2 g of Citrulline Malate for a "pre-workout" formulation.

C. Formulation Tips

Synergistic effect with yeast β-glucan (250 mg), showing a 46% increase in NK cell activity.

HPMC Pullulan is the preferred plant-based capsule to avoid delayed dissolution (disintegration time ≤15 min) caused by gelatin cross-linking.

2. Functional Foods & Beverages

A. Solubility & Organoleptics

Water Solubility Index (WSI): 96% (AOAC 960.48); readily disperses in cold water (25℃) without clumping.

Clarity: Turbidity <5 NTU; 660 nm clarity ≥95%, suitable for clear PET bottles.

Taste: Neutral mushroom flavor. Can be fully masked with just 40 ppm of vanilla.

B. pH & Shelf Stability

Activity Retention: >90% for polysaccharides and adenosine at pH 3-9, 63℃ for 30 min.

Compatibility: Excellent compatibility with citric, malic, and lactic acids. For carbonated systems with pH<3, we recommend adding 0.05% ascorbic acid as a color stabilizer to maintain a ΔE<1.5.

C. Thermal Processing Window

After UHT processing at 138℃ for 30 seconds, polysaccharide recovery is 97% and adenosine is 94%. Suitable for neutral milk beverages.

Recommendation: Aseptic post-addition is advised to preserve color.

D. Application Examples & Inclusion Rates

3. Cosmeceuticals & Skincare

A. In Vitro Antioxidant Activity

DPPH· IC₅₀: 1.84 mg/mL, 1.5x better than Trolox and 2.3x better than Vitamin E.

ABTS·⁺ IC₅₀: 0.91 mg/mL.

ORAC: 2,847 μmol TE/g.

B. Human Dermal Fibroblast (HDFa) Studies

Treatment: 0.1% (w/v) concentration for 48 hours.

Type I Collagen: Increased by 28% (ELISA).

Hyaluronic Acid Synthase-2 (HAS-2) mRNA: Increased 1.9-fold (RT-qPCR).

MMP-1: Decreased by 22% (Western blot).

Safety: Safe at concentrations ≤1% with no cytotoxicity (MTT assay, viability >95%).

C. Clinical Efficacy (Visible Results)

Trial: 1% inclusion in a cream, 32 subjects, applied twice daily for 28 days.

Skin Elasticity: Increased by 10.3% (Cutometer).

Transepidermal Water Loss (TEWL): Decreased by 12%.

Fine Line Volume: Decreased by 9.6% (3D Skin Surface Topography).

D. Formulation Recommendations

Solubility: Disperse in the 70℃ aqueous phase first, then homogenize at 3,000 rpm for 2 minutes to achieve a particle size D90 <50 µm.

Compatibility: Synergistic with 2% Niacinamide and 0.5% Panthenol for enhanced skin barrier function. Avoid co-formulating with >5% AHAs or in systems with a pH <3.5 to prevent polysaccharide degradation.

Regulatory: Included in the "Inventory of Existing Cosmetic Ingredients in China" #04738. INCI: Cordyceps Militaris Extract. A CIR-like safety assessment report is available upon request.

Request your free 50g sample today and receive the complete set of raw efficacy and stability data to help you achieve proof-of-concept within 30 days!

At Jiuyuan Bio, we believe that exceptional quality is born from extreme control over every single step. Our rigorous "Seed-to-Spec" traceability system ensures that every batch of our Organic Cordyceps Militaris Extract you receive is pure, potent, and reliably safe.

Organic Cultivation: Pure Origins in Qin Mountain's Heartland

Our Cordyceps is exclusively grown at our owned, certified organic farms in Shaanxi, China. Cultivated in Controlled Environment Agriculture (CEA) facilities, they are completely shielded from external pollutants. Grown on natural substrates, absolutely no chemical pesticides, herbicides, or synthetic fertilizers are ever used. Regular screening for heavy metals and contaminants in soil, water, and air ensures purity and safety from the very origin.

Scientific Harvesting: Precision Harvesting at Peak Potency

We move beyond traditional methods, relying on precise data to determine the optimal harvest time. Our agricultural experts have determined that at precisely 70 days of growth, when the fruit bodies reach 8-12 cm in length, the concentration of the key active compound-Adenosine-peaks at 0.25% of dry matter. This is the moment we harvest to ensure maximum efficacy. Careful hand-harvesting by experienced workers then selects only the highest-quality fruit bodies, with immediate processing to lock in freshness and bio-activity.

State-of-the-Art Extraction: Gentle Extraction for Maximum Bioavailability 

Within our GMP-certified facilities, we employ innovative low-temperature dynamic circulation extraction (at 40-45°C) using purified water only. This gentle process prevents the thermal degradation of heat-sensitive actives, such as cordycepin and polysaccharides. The extract is then purified and concentrated through a multi-stage membrane filtration system, requiring no alcohol or harsh chemical solvents. This proprietary technology ensures an exceptional active retention rate of ≥98%, delivering a final extract that is exceptionally pure, potent, and highly bioavailable for your formulations.

Rigorous Quality Control: Every Batch Verified, Every Promise Kept

Quality is not the last step but integrated into every step. Every batch of extract undergoes stringent testing in our in-house QC lab and by independent third-party labs. We utilize advanced instruments like HPLC and GC-MS to verify potency, purity, and ensure compliance with strict limits for microbiologicals, heavy metals, and pesticides, meeting USP, EP, and your market's specific requirements. A detailed Certificate of Analysis (COA) accompanies every batch, underscoring our commitment to transparency and quality.

Global Logistics: Securely Delivered to Your Doorstep

The finished product is packed in food-grade, moisture-proof, and light-resistant materials to guarantee stability during long-distance transportation. With extensive export experience and a reliable network of logistics partners, we offer flexible shipping solutions (air/ocean) to ensure your orders are delivered to your facility anywhere in the world efficiently and with clear traceability.
This is the Jiuyuan Bio Difference. It's more than an extract; it's a promise of excellence, backed by complete transparency.

Three distinct product types compete in the cordyceps ingredient market. Understanding their differences is not academic - it directly affects your finished product's efficacy, your label claims, and your brand's credibility with informed consumers.

Why C. sinensis CS-4 Falls Short for Modern Formulations

CS-4 is a mycelium fermentation product - not a fruiting body extract. It contains negligible cordycepin because the mycelial growth stage does not accumulate this nucleoside at meaningful concentrations. Brands positioning on cordycepin-driven mechanisms - VO₂ max, AMPK activation, endurance - cannot substantiate those claims with CS-4.

C. militaris fruiting body is the only commercially viable source of standardized, HPLC-verified cordycepin at supplement-relevant concentrations.

• Vertical Integration: We control every step from cultivation to extraction, ensuring unmatched consistency and supply stability. 
• Technical Expertise: Our in-house R&D team provides unparalleled technical support for your product development. 
• Customer-Centric Solutions: We offer flexible MOQs and custom formulation services for large-scale B2B orders. 

Packaging Configuration

We offer three standard packaging formats, each designed around a specific order volume and transit risk profile:

Standard Transit Options:

Sourcing cordyceps militaris extract powder involves a set of quality traps that catch even experienced procurement teams. Here is how to navigate them.

Step 1 - Define Your Specification Before Requesting Quotes

Lock down these variables before contacting any supplier:

• Primary bioactive target - cordycepin percentage, beta-glucan percentage, or both
• Assay method requirement - HPLC for cordycepin is non-negotiable for premium positioning
• Plant part requirement - fruiting body only; request microscopic confirmation
• Extraction type - water-extracted only, or dual extraction for full-spectrum profile
• Organic certification - USDA NOP, EU Organic, or both
• Destination market - determines required regulatory documentation package

Step 2 - Request the Right Documentation Package

A credible supplier provides all of the following without hesitation:

• Lot-specific COA with full parameter list
• HPLC chromatogram for cordycepin and adenosine - not UV absorbance only
• Enzymatic assay data for beta-glucan (alpha-glucan / beta-glucan breakdown)
• Heavy metals report (ICP-MS method)
• Pesticide residue report (EU MRL compliant)
• Valid cGMP and relevant market certifications
• MSDS/SDS
• If a supplier quotes a cordycepin percentage without an HPLC chromatogram to support it, that number is unverified.

Step 3 - Validate the Sample Independently

• Order 100g–500g before committing to commercial volume
• Submit to an accredited third-party laboratory for independent cordycepin verification by HPLC
• Request the alpha-glucan/beta-glucan breakdown - not just total polysaccharides
• Assess organoleptic properties: characteristic orange-brown color, earthy aroma, particle size consistency

Step 4 - Understand the Pricing Structure

Step 5 - Build Supply Chain Continuity

• Confirm lead times for both stock and custom grades
• Request batch-to-batch COA comparison across 3+ production lots to assess consistency
• Clarify packaging options and shelf life from manufacture date
• Discuss annual volume agreements for price stability and supply security

Q1: What is cordycepin and why does its concentration matter so much in formulation?

Cordycepin (3'-deoxyadenosine) is a naturally occurring adenosine analogue and the primary bioactive nucleoside in Cordyceps militaris. It is the compound most directly linked to the athletic performance, immune modulation, and anti-inflammatory effects documented in clinical research. Its concentration matters because the dose-response relationship is real - a product containing 0.3% cordycepin delivers a fundamentally different dose per serving than one containing 2% or 5%. For any formula making performance or immune claims, HPLC-verified cordycepin content is the number that determines whether your product can substantiate those claims.

Q2: What is the difference between Cordyceps militaris and Cordyceps sinensis?

They are distinct fungal species with different biology, cultivation profiles, and bioactive compositions. C. sinensis is the wild species historically used in traditional Chinese medicine - it parasitizes ghost moth larvae at high altitude and cannot be commercially cultivated to produce fruiting bodies. C. militaris produces cultivatable fruiting bodies under controlled indoor conditions and contains cordycepin at concentrations that can exceed those in wild C. sinensis by a substantial margin. For supplement formulation, C. militaris fruiting body extract is the commercially viable, scientifically documented, and cost-effective choice.

Q3: How do I verify that a cordyceps extract is genuinely fruiting body and not mycelium-on-grain?

Three verification methods work in combination. First, request an HPLC chromatogram showing cordycepin and adenosine peaks - mycelium-on-grain products typically show negligible cordycepin. Second, request an alpha-glucan/beta-glucan breakdown using an enzymatic assay - fruiting body shows 10%–40% true beta-glucan with negligible starch; mycelium-on-grain typically shows below 7% beta-glucan with 35%–40% starch. Third, request microscopic examination images of the raw material confirming fruiting body morphology. Any supplier unwilling to provide all three should be disqualified.

Q4: What clinical evidence supports cordyceps militaris in sports nutrition applications?

A randomized controlled trial published in 2024 examined C. militaris supplementation in healthy adults and found statistically significant improvements in VO₂ max, time to exhaustion, and inflammatory markers. The proposed mechanism involves AMPK pathway activation by cordycepin, which promotes mitochondrial biogenesis and enhances oxygen utilization efficiency. Earlier research published in the Journal of Dietary Supplements (2016) found that C. militaris supplementation improved VO₂ max in older adults over 12 weeks. These findings support positioning in endurance, aerobic capacity, and exercise recovery.

Q5: Is there a risk of heavy metal contamination in cordyceps extracts?

Fungi are efficient bioaccumulators of heavy metals from their growth substrate. This makes substrate control and incoming raw material testing critical for cordyceps ingredients. Our standard testing protocol includes ICP-MS analysis for Pb, As, Cd, and Hg on every incoming lot before processing begins and again on the finished extract. All commercial grades meet EU Regulation 396/2005 limits and US Pharmacopeia heavy metal guidelines. Full ICP-MS reports are available per batch.

Q6: What is the recommended dosage range for supplement formulations?

Published clinical studies have used daily doses ranging from 1,000mg to 4,000mg of C. militaris fruiting body material. For a 1% cordycepin extract, a 1,000mg daily serving delivers approximately 10mg of cordycepin. For a 2% grade, the same serving delivers 20mg. Industry formulation guidance for sports nutrition positioning typically targets 1,000mg–3,000mg per daily serving of a standardized extract. Finished product dosing should align with your target market's regulatory framework and specific health positioning.

Q7: Can cordyceps militaris extract powder be combined with other mushroom extracts?

Yes - and this is one of the most commercially active areas in the functional mushroom category. C. militaris extract is frequently combined with lion's mane (Hericium erinaceus), reishi (Ganoderma lucidum), and turkey tail (Trametes versicolor) in multi-mushroom immune and adaptogen formulas. The bioactive profiles are complementary rather than redundant: cordycepin drives nucleoside-mediated effects, lion's mane hericenones target nerve growth factor, and turkey tail PSK/PSP modulates innate immune response. We supply all four species and can provide matched COA documentation for multi-mushroom blend projects.

Q8: What markets do you currently supply, and what regulatory documents can you provide?

We supply customers across the United States, European Union, United Kingdom, Canada, Australia, Japan, South Korea, and the Middle East. Available regulatory documents include FDA facility registration confirmation, EU-format COA, Halal and Kosher certificates, USDA NOP and EU Organic certificates with transaction certificates per shipment, MSDS/SDS, and country-specific phytosanitary documentation where required. Contact info@jiuybiotech.com with your destination market for a tailored documentation checklist.

Jiuyuan Biotech supplies cordyceps militaris extract powder to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

Request: Sample| Bulk Quote | CoA & Spec Sheet | Custom Carrier Ratio

Standard response time: within 1 business day. Please include your target application and annual volume estimate for the most relevant technical recommendation.