Honeysuckle Extract Powder

Honeysuckle Extract Powder's principal active marker, chlorogenic acid (CAS 327-97-9), is a caffeoylquinic acid ester with one of the most extensively characterized antioxidant and anti-inflammatory profiles in the plant phenolic literature. Its co-constituent luteolin - a flavone with documented NF-κB inhibitory and antiviral activity - contributes a complementary mechanistic layer that extends the extract's utility across immune support, respiratory wellness, anti-inflammatory skincare, and natural beverage formulations.

At Jiuyuan Biotech, we source Lonicera japonica flower buds exclusively from Henan Province - the primary cultivation region recognized by the Chinese Pharmacopoeia for producing Flos Lonicerae Japonicae with the highest chlorogenic acid concentrations. Our extract is standardized to 5%–98% chlorogenic acid by in-house HPLC, with every batch released against a batch-specific COA that reflects actual measured values - not specification templates. Full documentation ships with every order: COA, MSDS, HPLC test reports, microbial analysis, heavy metal screening, and regulatory support for US, EU, and global markets.

Whether your application calls for a 5% grade in a multi-ingredient immune blend or a high-potency 50%+ grade for a concentrated antiviral botanical product, we hold inventory across all major specification tiers and can fulfill sample requests within days.

Below is the COA of Honeysuckle Extract Powder, please refer to it.

Lonicera japonica flower buds contain a phytochemical profile dominated by two structurally distinct classes - hydroxycinnamic acid derivatives and flavonoids - whose combined activity underpins the extract's broad pharmacological profile.

Hydroxycinnamic Acid Fraction

● Chlorogenic Acid (5-O-Caffeoylquinic Acid)

The principal active marker and the most abundant phenolic constituent in Lonicera japonica flower buds. Chlorogenic acid is an ester of caffeic acid and quinic acid with a well-characterized antioxidant mechanism involving direct free radical scavenging and metal chelation. Beyond antioxidant activity, peer-reviewed research documents its anti-inflammatory effects via NF-κB pathway inhibition and its capacity to modulate glucose metabolism - a finding that has expanded its application into metabolic health formulations.

● Isochlorogenic Acids A, B & C

A family of dicaffeoylquinic acid isomers co-occurring with chlorogenic acid in Lonicera japonica extracts. Research published in PMC documents their antiviral activity against multiple respiratory viruses, with isochlorogenic acid A demonstrating particularly potent inhibitory effects in cell-based antiviral assays. Their presence in a full-spectrum honeysuckle extract contributes activity dimensions that a single-compound chlorogenic acid isolate cannot replicate.

Flavonoid Fraction

● Luteolin

A flavone present in Lonicera japonica flower buds as both the free aglycone and as luteolin-7-O-glucoside. Research published in PMC identifies luteolin as one of the key bioactive components responsible for the extract's antioxidant and anti-inflammatory activity, with documented inhibition of pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) through NF-κB and MAPK signaling suppression.

Luteolin has also been investigated for antiviral activity against enveloped viruses, with proposed mechanisms including inhibition of viral entry and replication. A study published in PMC specifically examined the anti-inflammatory and antiviral effects of Flos Lonicerae Japonicae water extract, chlorogenic acid, and luteolin - confirming that both compounds contribute independently to the extract's antiviral efficacy rather than one being a passive co-constituent.

● Luteolin-7-O-Glucoside

The primary glycosylated form of luteolin in the flower bud. It exhibits greater water solubility than the free aglycone, which improves its bioavailability in aqueous formulation systems and functional beverage applications.

Iridoid Fraction

● Loganin & Secologanin

Minor iridoid glycosides present in Lonicera japonica that contribute to the extract's antibacterial activity, particularly against gram-positive pathogens. Their concentration in commercial extracts is lower than the phenolic and flavonoid fractions, but their presence in full-spectrum ratio extracts contributes to the whole-herb activity profile documented in TCM clinical literature.

● Raw Material Selection
High-grade honeysuckle flowers from trusted growers.

● Water/Ethanol Extraction
Gentle extraction to preserve heat-sensitive compounds.

● Purification & Concentration
Standardized chlorogenic acid levels (HPLC tested).

● Drying & Milling
Ensures uniform powder quality and good solubility.

● QC Testing
Active compounds, heavy metals, microbes-full compliance.

Choosing the correct specification depends on your product category and formulation goals. Below is our Reference Guide:

Honeysuckle extract's dual-class phytochemistry - phenolic acids and flavonoids - combined with its deep TCM heritage and growing modern research base positions it across multiple high-growth supplement and functional product categories.

1. Industry-Leading Production Capacity & Expertise

● 13+ years of experience in plant extract R&D and nutraceutical ingredient manufacturing

● 6 modern production workshops covering 70,000 m² and 10 automated extraction & purification lines

● Flexible purity (85% standard, 90–98% custom-grade), particle size (80–350 mesh), and custom packaging

2. Advanced Fermentation & Bio-Synthesis Capabilities

● Implements microbial fermentation and engineered bio-synthesis to produce Nervonic Acid

● Reduces seasonal raw material dependency, improving batch-to-batch consistency and bioactivity

● Supports sustainable and eco-friendly production

3. High-Quality & Batch Consistency

● Proprietary purification processes with HPLC, GC, ICP-MS, and moisture analysis

● Certificate of Analysis (COA) provided for every batch

4. Scientific R&D & Formulation Support

● 500 m² R&D center staffed with 12 scientists for formulation guidance, custom blends, and technical consultation

5. Certified & Compliant Production

● Facilities certified cGMP, FSSC 22000, ISO 22000, ISO 9001, HALAL, KOSHER

● Meets international quality standards for global markets

We know that different customers have different needs, so we provide customized packaging services.

We have a variety of standard packaging specifications, such as 25 kg/barrel, 50 kg/barrel, etc., to meet the purchasing volume needs of different customers. At the same time, we also support small packaging needs, such as 1 kg, 5 kg, etc., to facilitate customers in conducting small batch trials or special purposes. The use of environmentally friendly packaging materials not only meets international environmental standards but also reduces the impact on the environment.

The packaging design focuses on sealing and moisture resistance to ensure that the product is not damp or deteriorated during transportation and storage.

We have established long-term cooperative relations with many internationally renowned logistics companies and have a global logistics network. No matter where your destination is, we can ensure that the products are delivered on time and safely.

We can recommend the most suitable transportation method for you:

Sea transportation: suitable for large-volume, non-urgent orders, with lower costs and longer transportation time.

Air transportation: suitable for small-volume, urgent orders, short transportation time and higher costs.

Land transportation: suitable for orders in domestic or surrounding areas, with short transportation time and moderate costs.

Q1: What is the difference between chlorogenic acid from honeysuckle extract and chlorogenic acid from green coffee bean extract? Chlorogenic acid (CAS 327-97-9) is the same molecule regardless of botanical source - the chemical structure is identical. The difference lies in the co-constituent profile of the extract matrix. Green coffee bean extract contains primarily 5-O-caffeoylquinic acid (chlorogenic acid) with some 3- and 4-isomers, while Lonicera japonica extract contains chlorogenic acid alongside isochlorogenic acids A, B, and C (dicaffeoylquinic acid isomers) and luteolin - a broader phenolic profile that may contribute additional biological activity beyond what chlorogenic acid alone provides. For immune and antiviral applications, the full Lonicera japonica phytochemical matrix is the more relevant source.

Q2: Is honeysuckle extract powder approved for use in dietary supplements in the US and EU? In the United States, Lonicera japonica flower extract is marketed as a dietary ingredient under DSHEA with a history of use in Traditional Chinese Medicine. In the EU, it is used in food supplements and botanical preparations; however, Novel Food status should be verified for specific extract concentrations and product formats in specific member states. We provide regulatory support documentation and can connect you with our regulatory affairs contacts for market-specific guidance. Finished product label claim compliance remains the responsibility of the manufacturer.

Q3: What is the recommended chlorogenic acid grade for an immune support capsule formulation? For a multi-ingredient immune support blend, the 10% chlorogenic acid grade is the most commonly specified - it provides a meaningful active marker concentration at a cost-efficient price point for a product where honeysuckle is one of several active ingredients. For a single-ingredient or hero-ingredient immune product where honeysuckle is the primary active, the 25% grade provides stronger label substantiation. The 50% grade is primarily ordered for high-potency concentrated formats or research applications.

Q4: Can honeysuckle extract powder be used in functional beverage applications? The standard and mid-range chlorogenic acid grades (5%–10%) have acceptable water dispersibility for beverage applications when used at typical inclusion rates. At higher concentrations, the extract's phenolic content can contribute astringency and slight bitterness to the beverage matrix. For clean-tasting functional beverage applications, we recommend our microencapsulated grade, which uses a food-grade carrier to improve dispersibility and mask the characteristic phenolic taste profile. Contact our technical team for formulation-specific guidance.

Q5: How does honeysuckle extract compare to elderberry extract for immune support formulations? They operate through complementary rather than competing mechanisms. Elderberry extract (primarily anthocyanins) works primarily through cytokine modulation and direct antiviral activity against influenza viruses. Honeysuckle extract (chlorogenic acid, luteolin, isochlorogenic acids) provides broader-spectrum antiviral activity across multiple virus families alongside anti-inflammatory and antioxidant mechanisms. They are frequently combined in premium immune support formulas precisely because their mechanistic profiles are additive rather than redundant.

Q6: What is the veterinary application potential for honeysuckle extract powder? Research published in PMC documents the biological functions of Lonicera japonica in animal nutrition, including antibacterial activity against common livestock pathogens and antiviral effects relevant to poultry and swine production. The animal nutrition application is a growing segment for honeysuckle extract, particularly in markets where antibiotic growth promoter restrictions have created demand for botanical antimicrobial alternatives. We supply standard and ratio extract grades for veterinary nutrition applications; regulatory status varies by jurisdiction and species.

Q7: How should honeysuckle extract powder be stored to maintain chlorogenic acid stability? Store in a sealed, opaque container at 15–25°C, away from direct light, heat, and moisture. Chlorogenic acid is susceptible to oxidative degradation and photoisomerization under prolonged light exposure. We ship bulk material in double-layer polyethylene bags inside light-resistant fiber drums with desiccant packs. For high-potency grades (≥25% chlorogenic acid) and tropical destination markets, nitrogen-flushed packaging is strongly recommended and available on request.

Q8: Can you supply honeysuckle extract powder with organic certification? Organic-certified Lonicera japonica flower bud extract is available for select SKUs sourced from our certified cultivation bases. Organic certification requires dedicated raw material sourcing and segregated processing lines, which affects lead time and minimum order volume. Contact our sales team to confirm current certified inventory and applicable MOQ for organic grades. EU Organic (NOP) certification documentation is available for certified SKUs.

Jiuyuan Biotech manufactures and supplies Honeysuckle Extract Powder - standardized to chlorogenic acid, luteolin, or both - from our cGMP and ISO 22000 certified facility in Shaanxi, China, using Lonicera japonica flower buds harvested at peak potency from Henan Province cultivation bases. Every batch ships with a full HPLC-verified COA, pesticide residue report, and heavy metal data. Samples available from 1 kg. Commercial orders fulfilled from 5 kg with 7–14 business day lead time.

Request a Quote or Sample: Contact Us  info@jiuyuanbio.com

Direct Line: +86 029 88215052 

Facility: Hu County, Xi'an, Shaanxi Province, China

✅ ISO 9001 · FSSC 22000 · cGMP · FDA Registered · Halal · Kosher

Jiuyuan Biotech - your harvest-controlled, analytically verified source for bulk Honeysuckle Extract Powder.