Dahurian Angelica Root Extract

Discover Jiuyuan's Dahurian Angelica Root Extract, a natural furanocoumarin-rich compound derived from Angelica dahurica roots. Renowned for its potent bioactive properties, it's a top choice for cosmetic, pharmaceutical, and health supplement applications. Our rigorous extraction process ensures a high concentration of active components and zero heavy metal residue, meeting strict regulatory standards like the FDA and Halal.

Jiuyuan Biotechnology Co., Ltd., located in Hu County, Xi'an, is a leading manufacturer of Dahurian Angelica Root Extract. Sourced from premium Angelica dahurica plants in our dedicated Shaanxi cultivation base, our product ensures stable, high-quality raw materials. Our advanced production process, backed by cGMP and ISO22000 certifications, guarantees purity and consistency. With 10 cutting-edge production lines and an annual capacity of 6,000 tons, we offer customized solutions for the health food, functional food, and cosmetic industries. Jiuyuan's Dahurian Angelica Root Extract stands out for its high content of active compounds like imperatorin, zero pesticide residue, and compliance with global standards. 

Angelica dahurica root contains one of the most structurally diverse furocoumarin profiles among commercially available botanical extracts. Each compound contributes distinct biological activity.

Imperatorin

The primary furocoumarin marker and the most extensively studied compound in Angelica dahurica. Imperatorin is a linear furocoumarin (psoralen-type) with a well-documented pharmacological profile:

• Analgesic activity - Research published in European Journal of Pharmacology documents imperatorin's inhibition of prostaglandin synthesis and its modulation of pain signaling pathways, supporting Bai Zhi's traditional use for headache and facial pain
• Anti-inflammatory signaling - Imperatorin suppresses NF-κB activation and reduces TNF-α, IL-6, and IL-1β expression in macrophage models
• Antimicrobial activity - Documented inhibitory activity against Staphylococcus aureus, Streptococcus species, and several dermatophyte fungi
• Tyrosinase inhibition - Imperatorin inhibits tyrosinase activity, the rate-limiting enzyme in melanin biosynthesis, providing a mechanistic basis for skin-brightening applications

Isoimperatorin

A structural isomer of imperatorin with overlapping but distinct biological activity. Isoimperatorin contributes to the extract's anti-inflammatory and antispasmodic profile and serves as a secondary HPLC marker for quality standardization. Research in Phytochemistry documents its calcium channel antagonist activity, relevant for smooth muscle relaxation applications.

Byakangelicin

An angular furocoumarin with notable antimicrobial and anti-inflammatory properties. Byakangelicin has been studied for its activity against respiratory pathogens and its synergistic interaction with imperatorin in anti-inflammatory assays. Its presence in the full-spectrum extract contributes to the entourage effect that distinguishes whole-extract preparations from isolated single compounds.

Oxypeucedanin

A furocoumarin with documented antifungal and anti-inflammatory activity. Oxypeucedanin is present in meaningful concentrations in Angelica dahurica root and contributes to the extract's broad antimicrobial spectrum. It has also been studied for potential antiproliferative activity in cell line models.

Bergapten (5-Methoxypsoralen)

A linear furocoumarin with well-established photosensitizing properties. Bergapten is present in Angelica dahurica extract at low concentrations. Formulators developing topical cosmetic products must account for bergapten content - EU Cosmetics Regulation (EC) No 1223/2009 restricts 5-methoxypsoralen in rinse-off and leave-on cosmetic products. We provide bergapten quantification data on request for cosmetic-grade buyers.

Phellopterin and Xanthotoxin

Additional minor furocoumarins that contribute to the overall bioactive profile. These compounds add depth to the extract's antimicrobial and anti-inflammatory activity and are useful secondary markers for authenticating full-spectrum Angelica dahurica preparations.

Based on its mechanisms, Dahurian Angelica Root Extract offers several benefits:

• Whitening and Spot Reduction: It inhibits tyrosinase activity to reduce melanin production, helping to even out skin tone and fade spots.
• Anti-inflammatory and Pain-relieving: It can help relieve pain caused by inflammation, with an auxiliary effect for conditions like arthritis and muscle aches.
• Antibacterial and Anti-inflammatory: It helps prevent and treat various skin infections and inflammation, and can soothe sensitive, red skin.
• Antioxidant: It scavenges free radicals, which can reduce fine lines and wrinkles, improve skin elasticity, and slow down skin aging.

Raw Material Pre-processing:

• Selection and Cleaning: Select dry Dahurian Angelica roots free of mold and insects. Remove impurities and fine roots, and rinse quickly with water to prevent the loss of active compounds.
• Crushing: Crush the clean roots into 20-40 mesh particles to increase the surface area for extraction.
• Drying: Dry at a low temperature (60-70℃) until the moisture content is ≤8% to prevent spoilage.

Extraction Process (Ethanol Reflux):

• Extraction: Place the crushed root particles into an extraction tank. Add 8-10 times the volume of 70%-80% ethanol and reflux at 80-85℃ for 2-3 times, 2-3 hours each. Combine the extracts. (Note: The ethanol concentration and extraction time can be adjusted based on the target components. For example, water extraction and alcohol precipitation can be used for polysaccharides.)
• Filtration: Use a plate-and-frame filter or centrifuge (3000-5000 rpm) to remove residue from the extract, resulting in a clear filtrate.

Concentration and Purification:

• Vacuum Concentration: The filtrate is concentrated under vacuum (0.08-0.09 MPa, 50-60℃) to recover the ethanol (which can be recycled), resulting in an extract with a relative density of 1.2-1.3.
• Purification: For a high-purity extract, a macroporous resin adsorption method (e.g., D101 resin) can be used. The eluent is 50%-60% ethanol, which further removes impurities (e.g., starch, protein) and increases the content of active components.

Drying and Forming:

• Drying: The purified extract is dried using spray drying (inlet temperature 180-200℃, outlet temperature 80-90℃) or vacuum freeze-drying to produce Dahurian Angelica Root Extract powder.
• Crushing and Sieving: The dried powder is crushed and sieved through an 80-100 mesh screen to ensure uniform particle size.
• Quality Control and Packaging: The product is tested for key metrics, including the content of active components (e.g., imperatorin), moisture, and microbial limits. After passing, it's sealed in aluminum foil bags or cardboard drums and stored in a cool, dry place.

Formulation Compatibility Notes

• Capsule / tablet formats: High-potency grade blends well with standard excipients. Light-protective packaging for finished products is recommended given furocoumarin photosensitivity.
• Topical cosmetic formats: Cosmetic-grade extract with bergapten quantification data is essential for EU market compliance. Ethanol-extracted grades show good compatibility with common cosmetic carrier systems (propylene glycol, glycerin, emollient esters).
• Classical TCM pairings: Angelica dahurica pairs traditionally with Ligusticum chuanxiong (Chuan Xiong) for headache formulas and with Magnolia officinalis bark for sinus and respiratory applications - both pairings are documented in classical TCM literature and offer differentiated positioning for Western herbal markets.
• Oral care applications: The extract's antimicrobial activity against oral pathogens (Streptococcus mutans, Porphyromonas gingivalis) makes it a functional ingredient for natural oral care product development.

Our Dahurian Angelica Root Extract product stands out in the market due to these unique advantages:

• High Active Ingredient Content: We standardize and control the content of key active compounds, such as imperatorin and isoimperatorin, ensuring their levels are higher than the industry average.
• Natural and Additive-Free: The entire production process avoids the use of harmful chemical solvents, guaranteeing a pure, natural, and pollution-free product.
• Traceability: We have a comprehensive quality control and traceability system from cultivation to the final extraction, ensuring the safety and quality of every batch.
• Professional Technical Support: We provide professional application solutions and technical support to help clients effectively incorporate our product into their final products.

Buyers formulating headache relief, sinus support, skin-brightening, or anti-inflammatory products often evaluate Angelica dahurica alongside a familiar set of alternatives. Here's an honest positioning:

Where Dahurian Angelica Root Extract stands apart: It is one of the few botanical extracts that bridges the nutraceutical and cosmetic markets with a single, well-characterized furocoumarin profile. Imperatorin's dual role as an anti-inflammatory compound and a tyrosinase inhibitor gives formulators a genuine multi-application ingredient - one with deep TCM credibility and a growing Western research base. No synthetic skin-brightening agent carries that combination of traditional use documentation and mechanism-linked bioactivity.

At JIUYUAN BIOTECH, product quality is our top priority. We achieve this through a comprehensive and robust quality control system that meticulously manages every stage of production with scientific rigor. By strictly adhering to operational protocols, we ensure the traceability of every batch of our products. Shaanxi jiuyuan Bio currently holds numerous domestic and international industry certifications and qualifications, including cGMP Dynamic Drug Production Management StandardCertification, EU/USDAORGANIC Certification, SC Food Production License, IS0900 Quality Management System Certifica-tion, IS022000 Food Safety Management System Certification, FSSC22000 Global Standard for Food Safety, Health Food Raw Material Production License, HACCP(Hazard Analysis and Critical Control Points)System Certification, Kosher Certification, Halal Certification, and FDA registration. Our operations in production, research and development, and sales consistently meet the requirements of these demanding standards. With advanced production facilities, a state-of-the-art testing and control center, and our complete quality control system, we consistently ensure the safety and stability of our products and services.

Founded in 2012, Shaanxi Jiuyuan Biotechnology Co., Ltd. is based at the northern foot of the Qinling Mountains in Huyi District, Xi'an City. We are a dynamic high-tech enterprise that integrates the research and development, production, and sales of plant extracts and fruit and vegetable powders. For many years, our company has been committed to delivering high-quality products and services to customers in the health food, food, and cosmetic industries, with a strong drive to lead China's plant extract industry.

We are equipped with state-of-the-art testing equipment, such as HPLC and UV spectrometers, enabling precise analysis of active ingredient content and purity. Our professional testing team provides detailed product analysis reports, ensuring product quality and safety.

We have established long-term, stable partnerships with local farmers to ensure a consistent supply of raw materials. Through contract farming and procurement, we guarantee the quality and quantity of raw materials, providing reliable material assurance to our clients.

We possess comprehensive production and warehousing facilities to meet large-volume client demands. Our factory is equipped with advanced production equipment and automated production lines, enabling efficient production of high-quality products. Our warehousing facilities provide optimal storage conditions, ensuring product quality and stability during storage.

Express Under 100kg, 3-5Days Door-to-door service easy to pick up the goods	By Sea Over300kg, Around 30 Days Port-to-port service professional clearance broker needed	By Air 100kg-1000kg, 5-7Days Airport-to-airport service professional clearance broker needed

Storage: Keep in a cool, dry, and clean place. Protect from moisture and direct light.

Bulk Package: 25kg/drum.

Lead Time: 7 days after your order.

Shelf Life: 2 years.

Remark: Customized specifications can also be achieved.

Who Sources This Extract?

• Dietary supplement brands building headache relief, sinus support, or anti-inflammatory SKUs
• Cosmetic and personal care companies developing skin-brightening, anti-acne, or anti-aging topical products
• Oral care product developers seeking natural antimicrobial actives
• Pharmaceutical companies sourcing standardized TCM intermediates
• Contract manufacturers needing a document-ready botanical for multi-ingredient formulas
• Private label brands entering the TCM-inspired wellness or natural beauty category

Critical Verification Points Before You Order

1. Confirm Species Authentication Angelica dahurica adulteration is a documented supply chain risk. Request a TLC fingerprint report and confirm the supplier performs species-specific authentication - not just macroscopic visual inspection.

2. Verify Imperatorin by HPLC with Certified Reference Standard Imperatorin is the primary value marker. HPLC quantification must use a certified imperatorin reference standard. Ask the supplier to specify the analytical method, column type, and reference standard source.

3. Request Bergapten Data for Cosmetic Applications If you're developing a leave-on or rinse-off cosmetic product for EU markets, bergapten content must be quantified and confirmed compliant with EU Cosmetics Regulation (EC) No 1223/2009 limits. This is a regulatory requirement, not a preference.

4. Check Pesticide Compliance for Your Target Market Angelica dahurica is cultivated across regions with varying agricultural practices. A multi-residue pesticide screen compliant with EU Regulation 396/2005 or USP <561> is the minimum acceptable standard for regulated market entry.

5. Confirm Light-Protected Packaging Furocoumarins degrade under UV and visible light exposure. Confirm that finished extract is packed in opaque, foil-lined packaging - not transparent bags or containers.

6. Assess Residual Solvent Compliance Ethanol-extracted grades must comply with ICH Q3C Class 3 solvent limits for pharmaceutical applications, or applicable food safety regulations for supplement and food use. Request the residual solvent test report.

Q1: What is the difference between Angelica dahurica and Angelica sinensis (Dong Quai)?

These are two distinct species within the Angelica genus with different phytochemical profiles and different traditional applications. Angelica dahurica (Bai Zhi) is characterized by its furocoumarin content - imperatorin, isoimperatorin, byakangelicin - and is used traditionally for headache, sinus conditions, and skin disorders. Angelica sinensis (Dong Quai) is characterized by ferulic acid and phthalide compounds (ligustilide, butylidenephthalide) and is used primarily for gynecological and blood-nourishing applications. They are not interchangeable in formulation. Confirm the species with your supplier before ordering.

Q2: Is Dahurian Angelica Root Extract safe for use in cosmetic products?

The extract has a long history of use in traditional cosmetic preparations across East Asia. For modern regulated cosmetic markets, the key safety consideration is bergapten (5-methoxypsoralen) content. EU Cosmetics Regulation (EC) No 1223/2009 restricts 5-methoxypsoralen to a maximum of 1 mg/kg in leave-on products and 10 mg/kg in rinse-off products. We provide bergapten quantification data for cosmetic-grade batches. Buyers should conduct a full safety assessment (including phototoxicity evaluation) before market launch in regulated markets.

Q3: Can this extract be used in US dietary supplements under DSHEA?

Angelica dahurica root has a documented history of use as a dietary ingredient and is not listed on the FDA's prohibited or restricted ingredients list for dietary supplements. Under DSHEA (Dietary Supplement Health and Education Act), it can be used in dietary supplements provided it meets safety and labeling requirements. For new dietary ingredient (NDI) considerations, consult your regulatory affairs team. We provide full documentation support including COA, MSDS, and country of origin certificates for US market compliance.

Q4: What is the recommended inclusion rate for a headache or sinus support supplement?

Based on published ethnopharmacological references and TCM clinical practice guidelines, typical daily doses of Angelica dahurica root in traditional preparations range from 3g to 9g of dried root. For a standardized extract at 5% total coumarins, this translates to an approximate inclusion rate of 200 mg to 500 mg per serving in finished supplement products. Your formulation team should validate the final dosage against your specific label claims and target market regulations.

Q5: How do you distinguish your extract from lower-quality Angelica dahurica products on the market?

Three specific quality markers separate our extract from commodity alternatives. First, we perform species-specific TLC authentication on every incoming raw material lot - not just visual inspection. Second, we quantify imperatorin and isoimperatorin separately by HPLC using certified reference standards, rather than reporting only total coumarins by UV spectrophotometry. Third, we maintain light-protected conditions throughout extraction, concentration, and packaging - a step that many commodity suppliers skip, resulting in measurable furocoumarin degradation before the product reaches the buyer.

Q6: Is the extract suitable for use in natural oral care products?

Yes. The antimicrobial activity of Angelica dahurica furocoumarins against oral pathogens - including Streptococcus mutans (a primary cariogenic bacterium) and Porphyromonas gingivalis (associated with periodontal disease) - has been documented in peer-reviewed literature. The extract is used in traditional Chinese oral care preparations and is gaining traction in the natural oral care segment in Western markets. For mouthwash or toothpaste applications, we recommend the water-soluble grade for better dispersibility in aqueous formulations.

Q7: Do you offer extraction ratio grades (e.g., 10:1) in addition to standardized marker grades?

Yes. We produce both standardized marker-compound extracts (imperatorin ≥ 0.5%, total coumarins ≥ 5%) and traditional concentration-ratio extracts (4:1, 10:1, 20:1). Ratio-based extracts are preferred for buyers formulating products for markets where ratio-based labeling is conventional - particularly in some Asian and European herbal product categories. Standardized marker-compound extracts are preferred for US dietary supplement labeling and clinical-grade applications. Specify your labeling convention and target market when requesting a quotation.

Q8: What storage conditions do you recommend for the finished extract?

Store in a cool (below 25°C), dry (relative humidity below 60%), dark environment. Avoid exposure to direct light - furocoumarins are photosensitive and will degrade under UV and visible light exposure over time. Keep containers tightly sealed when not in use. Under these conditions, the extract maintains specification for 24 months from the production date. We provide stability data confirming these shelf-life parameters upon request.

Jiuyuan Biotech supplies Dahurian Angelica Root Extract to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

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