Organic Celery Seed Extract

Organic Celery Seed Extract is a highly standardized, natural botanical extract derived from the mature seeds of organically grown celery (Apium graveolens L.). This product undergoes a meticulous extraction and purification process to ensure the core active ingredient, Apigenin, is precisely controlled to a content ranging from 0.5% to 98%. As a potent natural flavonoid, it is widely used in high-end nutritional supplements, functional foods, and pharmaceutical applications.

At Jiuyuan Biotech, we manufacture Organic Celery Seed Extract under USDA NOP and EU Organic certification, standardized by HPLC to a defined phthalide content, and tested on every batch for identity, potency, heavy metals, pesticide residues, and microbiology before release. What follows is the technical dossier your formulation and regulatory teams need to make an informed sourcing decision.
Source and Characteristics

• Botanical Source： Dried mature seeds of celery (Apium graveolens L.) from the Apiaceae family.
• Organic Certification： Raw material sourced from certified organic celery seeds, guaranteeing no use of synthetic pesticides, chemical fertilizers, or genetically modified organisms (GMOs) during cultivation and harvest.
• Appearance： Typically a light-yellow, fine powder with the characteristic mild aroma of celery seeds.

The bioactive profile of Apium graveolens seed is anchored by three compound classes: phthalides, flavones, and phenolic acids. Understanding the distinct roles of each class - and the interactions between them - is essential for positioning your finished product accurately and building a defensible research narrative.

Phthalides - The Primary Bioactive Class

Phthalides are a group of isocoumarin-related lactone compounds found almost exclusively in the Apiaceae (Umbelliferae) family. Apium graveolens seed is the richest dietary source of phthalides identified to date. The principal phthalides in celery seed include:

n-Butylphthalide (3nB)

The most pharmacologically studied phthalide in celery seed. 3nB is responsible for a significant portion of celery's characteristic aroma and has been the subject of substantial preclinical research. Key documented bioactivities in peer-reviewed literature include:

• Vasorelaxant activity: 3nB has been shown to relax vascular smooth muscle in isolated aortic ring preparations, with a proposed mechanism involving calcium channel antagonism and inhibition of prostaglandin biosynthesis. Research published in Planta Medica (Tsi & Tan, 1996) demonstrated significant antihypertensive effects of celery seed extract in animal models, with the phthalide fraction identified as the primary active component.
• Anti-inflammatory activity: 3nB inhibits the production of arachidonic acid metabolites via the cyclooxygenase (COX) pathway in preclinical models, providing a mechanistic basis for the traditional use of celery seed in inflammatory joint conditions.
• Neuroprotective activity: 3nB has been studied in animal models of ischemic stroke and Alzheimer's disease, where it demonstrated neuroprotective effects attributed to antioxidant activity, anti-neuroinflammatory mechanisms, and inhibition of acetylcholinesterase. This is an active and expanding research area.
• Uricosuric activity: Celery seed preparations have been studied for their ability to promote uric acid excretion in preclinical models, with the phthalide fraction proposed as a contributing active component.

Sedanolide and Sedanenolide

Closely related phthalides that contribute to the volatile oil profile of celery seed. Sedanolide has demonstrated antioxidant activity in vitro and contributes to the characteristic warm-spicy aroma of celery seed extract. These compounds are present in lower concentrations than 3nB but contribute to the overall phthalide bioactivity profile.

Butylphthalide (BP) and Other Phthalide Isomers

Celery seed contains a family of related phthalide structures including cis- and trans-isomers and their dihydro derivatives. The relative proportions of these isomers vary with seed origin, growing conditions, and processing method. HPLC fingerprinting of the phthalide fraction provides a more complete characterization of extract quality than single-compound assay alone.

Flavones

Apigenin (as Apiin - Apigenin-7-O-apiosylglucoside)

Celery seed is a concentrated source of apigenin, present primarily as the glycoside apiin. Apigenin is a flavone that has been studied for anti-inflammatory activity (NF-κB pathway inhibition), anxiolytic effects (GABA-A receptor modulation), and antioxidant activity. The glycosylated form (apiin) provides improved stability compared to the free aglycone and is hydrolyzed to free apigenin in the gastrointestinal tract.

Luteolin

A dihydroxylated flavone structurally related to apigenin, with well-characterized anti-inflammatory and antioxidant properties. Luteolin has been studied for its ability to inhibit pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) in macrophage models, providing complementary anti-inflammatory activity to the phthalide fraction.

Phenolic Acids

Caffeic Acid and Chlorogenic Acid

Both compounds contribute to the total antioxidant capacity of the extract and are well-characterized across multiple botanical sources for their anti-inflammatory and antioxidant bioactivities.

Bioactivity Summary Table

At JIUYUAN BIOTECH, product quality is our top priority. We achieve this through a comprehensive and robust quality control system that meticulously manages every stage of production with scientific rigor. By strictly adhering to operational protocols, we ensure the traceability of every batch of our products.

Shaanxi Jiuyuan Bio currently holds numerous domestic and international industry certifications and qualifications, ensuring our operations in production, R&D, and sales consistently meet demanding standards. Our key certifications include:

With our advanced production facilities, a state-of-the-art testing and control center, and our complete quality control system, we consistently ensure the safety and stability of our products and services.

The mechanism of action for Organic Celery Seed Extract is primarily based on its multi-target, multi-pathway biological regulatory effects:

Uric Acid Reduction Mechanism:

Inhibits xanthine oxidase (XOD) activity, reducing uric acid production.

Promotes uric acid excretion, lowering serum uric acid levels.

Combats oxidative stress and protects renal function.

Anti-inflammatory Mechanism:

Decreases pro-inflammatory factors (e.g., IL-1β, TNF-α).

Increases anti-inflammatory factor levels (e.g., IL-10).

Alleviates joint swelling and inflammatory responses.

Cardiovascular Mechanism:

Vasodilatory Effect: Exhibits significant vasodilation, which helps support healthy blood pressure levels by mediating the nitric oxide (NO) signaling pathway and regulating voltage-dependent calcium channels.

Lipid-Lowering Effect: Can lower blood lipid levels by regulating the AMPK signaling pathway and promoting reverse cholesterol transport.

• Uric Acid Reduction: Inhibits uric acid production and promotes excretion, alleviating hyperuricemia and gout.
• Anti-inflammatory and Analgesic for Gout Relief: Effectively prevents and relieves hyperuricemia and gout by inhibiting uric acid formation and reducing inflammation, also easing pain caused by rheumatoid arthritis and osteoarthritis.
• Cardiovascular Health Maintenance: Helps regulate healthy blood pressure and blood lipid levels, and provides anti-atherosclerotic and antioxidant protection for vascular endothelial cells.
• Antioxidant and Anti-aging: Acts as a powerful natural antioxidant, protecting cells from free radical damage and slowing down the aging process.
• Mood and Sleep Support: Possesses natural relaxing and calming properties, which can help stabilize mood and improve sleep quality.

• Raw Material Pretreatment: Cleaning, drying, and crushing.
• Enzyme-Assisted Extraction: To enhance the release rate of Apigenin.
• Solvent Extraction: Typically, 55% - 80% ethanol reflux extraction repeated 2–4 times.
• Filtration and Concentration: Vacuum concentration to recover the solvent.
• Purification: Methods like column chromatography and crystallization are used to increase Apigenin content.
• Drying and Pulverization: Spray drying into a powder; the organic celery seed extract is then sieved and sterilized.
• Packaging: Packed in aluminum foil bags or cardboard drums, stored in a light-proof, dry environment.

Dietary Supplements

Functional Food & Beverage

• Functional teas and herbal infusions: Celery seed is a traditional ingredient in herbal tea blends targeting fluid balance and joint comfort; extract powder can be incorporated into tea stick formats
• Sports nutrition recovery formulas: Anti-inflammatory positioning alongside curcumin, boswellia, or omega-3 ingredients
• Alkalizing beverage powders: Combined with other alkaline-forming botanical extracts for pH-balance and uric acid support positioning

Cosmetics & Personal Care

• Anti-aging topical formulations: Apigenin and luteolin antioxidant activity for free radical protection and skin-calming claims
• Scalp care products: Anti-inflammatory flavone content for scalp health and sensitivity positioning
• Aromatherapy blends: Celery seed essential oil fraction for its characteristic warm, spicy-green aroma profile

Veterinary Supplements

Celery seed preparations have a documented history of use in equine and canine joint health supplements, particularly for uric acid management and anti-inflammatory support in working animals

• Natural and Organic: Raw materials are sourced from organic cultivation bases, complying with green food standards.
• High Purity and Customizable: Apigenin content is flexibly customizable from 0.5% to 98%, meeting diverse formulation needs.
• Multi-functional: Simultaneously offers multiple health benefits, including uric acid reduction, anti-inflammation, antioxidation, and blood pressure support.
• Broad Applicability: Highly adaptable, suitable for use across multiple industries such as food, health supplements, and cosmetics.
• Mature Process: Supported by advanced techniques like enzyme-assisted, ultrasonic, and column chromatography extraction, ensuring high extraction efficiency.

Organic Celery Seed Extract vs. Competing Cardiovascular & Joint Health Botanicals

For formulators building cardiovascular wellness or joint health supplements, Organic Celery Seed Extract competes in a category alongside several well-established botanical actives. Here's an honest comparison on the parameters that matter to supplement formulators.

The formulator's read: Celery seed extract's competitive advantage is its specificity - the phthalide fraction targets vascular smooth muscle relaxation through a mechanism distinct from most other botanical cardiovascular actives, making it a genuinely additive ingredient in combination formulas rather than a redundant one. Its limitation is the relative scarcity of large-scale human clinical trials compared to garlic or olive leaf. The strategic play is to combine celery seed extract with ingredients that have stronger clinical substantiation, using celery seed's unique mechanism and organic positioning as differentiators.

Organic vs. Conventional Celery Seed Extract

Why organic matters specifically for celery: Celery is consistently ranked among the highest-pesticide-residue crops in conventional agriculture - it appears regularly on the Environmental Working Group's (EWG) "Dirty Dozen" list of produce with the highest pesticide residue levels. For a botanical extract derived from celery seed, organic certification is not merely a marketing premium - it is a meaningful risk-reduction measure that directly affects the pesticide residue profile of the finished extract. For supplement brands selling into the EU market, where pesticide MRL enforcement is stringent, organic-certified raw material provides a substantially cleaner compliance baseline.

Founded: 2012, based in Xi'an at the northern foot of the Qinling Mountains.

Business Scope: A high-tech enterprise specializing in the R&D, production, and sales of plant extracts and fruit and vegetable powders.

Mission: Committed to providing high-quality products and services to the health food, food, and cosmetics industries, to lead China's plant extract sector.

R&D and Quality Control:

Equipped with advanced testing equipment, including HPLC and UV spectrometers, for precise analysis of active ingredient content and purity.

A professional testing team provides detailed product analysis reports to ensure quality and safety.
Supply Chain Management:

Maintains long-term, stable partnerships with local farmers.

Utilizes a contract farming and procurement model to guarantee a consistent supply of high-quality raw materials.
Production and Warehousing:

Boasts comprehensive production facilities with advanced equipment and automated lines to meet large-volume demands.

Our robust warehousing system ensures optimal storage conditions, maintaining product quality and stability.

Express Under 100kg, 3-5Days Door-to-door service easy to pick up the goods	By Sea Over300kg, Around 30 Days Port-to-port service professional clearance broker needed	By Air 100kg-1000kg, 5-7Days Airport-to-airport service professional clearance broker needed

We offer three standard packaging formats, each designed around a specific order volume and transit risk profile:

Q1: What is 3-n-butylphthalide (3nB), and why does it matter for cardiovascular supplement formulation?

3-n-Butylphthalide (3nB) is a phthalide lactone compound found in highest concentrations in Apium graveolens (celery) seed, making celery the primary dietary source of this compound class. It is responsible for a significant portion of celery's characteristic aroma and has been the most extensively studied phthalide in the celery seed phytochemical profile.

From a formulation standpoint, 3nB is relevant for two primary reasons. First, it has demonstrated vasorelaxant activity in isolated vascular smooth muscle preparations - the proposed mechanism involves calcium channel antagonism and inhibition of prostaglandin synthesis, both of which are distinct from the mechanisms of most other botanical cardiovascular actives. This mechanistic distinctiveness makes 3nB genuinely additive in combination cardiovascular formulas rather than redundant. Second, it provides a specific, HPLC-verifiable marker compound for standardization - meaning you can specify a defined potency, verify it analytically, and build a consistent product rather than relying on bulk UV-measured "phthalide" content that may not accurately reflect bioactive potency.

The limitation is that large-scale human clinical trials specifically on standardized 3nB-containing celery seed extract are limited. The strongest evidence base is preclinical (in vitro and animal models), with traditional use providing historical context. This is an important consideration for regulatory claim substantiation in markets with strict evidence requirements.

Q2: Why does the organic certification matter specifically for celery seed extract, beyond marketing?

This is a substantive question with a practical answer. Celery - the whole plant, including the seed - is a crop with historically high pesticide residue levels in conventional agriculture. The Environmental Working Group (EWG) has consistently ranked fresh celery among the highest-residue produce items in its annual Dirty Dozen analysis, reflecting the intensive pesticide programs used in conventional celery cultivation.

For a botanical extract, the concentration process that increases phthalide content also concentrates pesticide residues if they are present in the raw material. An extract produced from conventionally grown celery seed with residue levels at or near the EU MRL limit could produce a finished extract with residue concentrations that exceed EU supplement product limits after concentration.

Organic certification addresses this at the source. Certified organic celery seed is grown without synthetic pesticides, and the organic chain-of-custody documentation provides a traceable, audited record of that status from farm to finished extract. For brands selling into the EU market - where pesticide MRL enforcement for food supplements is stringent and increasingly scrutinized - organic-certified raw material is a meaningful risk-reduction measure, not merely a label premium.

Q3: What is the difference between "total phthalides by UV" and "3nB by HPLC," and which specification should I require?

This distinction is practically important and frequently misunderstood in the market.

Total phthalides by UV is a bulk spectrophotometric measurement that quantifies all UV-absorbing compounds in the phthalide fraction collectively. It is a relatively straightforward and inexpensive assay, but it has a significant limitation: it does not distinguish between individual phthalide compounds. The celery seed phthalide fraction contains multiple structurally related compounds - 3nB, sedanolide, sedanenolide, butylphthalide isomers, and others - with varying bioactivities. A UV-measured "85% phthalides" figure tells you the total concentration of this compound class but does not tell you how much of the pharmacologically most-studied compound (3nB) is actually present.

3nB by HPLC is a compound-specific assay using high-performance liquid chromatography with UV detection, which separates and quantifies 3nB as an individual compound. This is the analytically rigorous specification for any application where 3nB content is relevant to the product's efficacy narrative.

Our recommendation: always require both specifications. The UV total phthalides figure gives you a broad potency indicator; the HPLC 3nB figure tells you the content of the compound with the strongest research narrative. If a supplier can only provide the UV figure and cannot produce an HPLC chromatogram with a verified 3nB peak, treat that as a significant quality documentation gap.

Q4: How should Organic Celery Seed Extract be handled and stored to maintain 3nB stability?

3nB is a volatile lactone compound with meaningful susceptibility to both evaporative loss and oxidative degradation. Proper handling and storage are not optional considerations - they directly affect the potency of the extract at the time of use in your manufacturing process.

Storage conditions:

• Temperature: ≤25°C (refrigerated storage at 2–8°C significantly extends 3nB stability for long-term inventory)
• Humidity: ≤60% RH (the extract is moderately hygroscopic; moisture ingress accelerates both microbial growth and phthalide hydrolysis)
• Light: Store in opaque packaging away from direct light (phthalides are photosensitive)
• Atmosphere: Keep sealed in nitrogen-flushed packaging until point of use; minimize headspace exposure after opening

Handling in manufacturing:

• Minimize time between opening packaging and incorporation into the formula
• Avoid high-temperature processing steps (e.g., fluid bed drying at high inlet temperatures) after incorporation
• For encapsulation: standard hard capsule filling at ambient temperature is compatible with 3nB stability
• For tablet compression: avoid high-temperature granulation; direct compression or low-temperature wet granulation is preferred

Our 24-month real-time stability data (25°C / 60% RH) confirms that 3nB content remains within specification throughout the stated shelf life in sealed, nitrogen-flushed packaging. Stability data is available on request.

Q5: Is Organic Celery Seed Extract suitable for combination formulas, and what ingredients pair well with it?

Yes - and combination formulation is arguably where celery seed extract delivers its strongest commercial value proposition. Its phthalide-mediated vasorelaxant and anti-inflammatory mechanisms are mechanistically distinct from most other botanical cardiovascular and joint health actives, making it genuinely additive rather than redundant in a well-designed combination formula.

Cardiovascular wellness combinations:

• Celery seed extract + aged garlic extract: Complementary mechanisms (phthalide vasorelaxation + allicin-mediated platelet aggregation inhibition); both have established cardiovascular research narratives
• Celery seed extract + olive leaf extract (oleuropein): Synergistic antioxidant and anti-inflammatory activity; both support vascular health through distinct pathways
• Celery seed extract + CoQ10: Mitochondrial energy support combined with vascular tone modulation; a logical pairing for comprehensive cardiovascular wellness positioning

Joint health / uric acid support combinations:

• Celery seed extract + tart cherry extract: The most commercially established combination in the natural uric acid support category; tart cherry anthocyanins and celery seed phthalides provide complementary mechanisms
• Celery seed extract + quercetin: Quercetin inhibits xanthine oxidase (the enzyme that produces uric acid); celery seed supports uric acid excretion; mechanistically synergistic for gout support positioning
• Celery seed extract + boswellia: Complementary COX-pathway anti-inflammatory activity for joint comfort formulas

Our technical team can provide formulation guidance, suggested inclusion levels, and compatibility data for your specific combination formula design.

Q6: What are the EU regulatory requirements for selling a supplement containing Organic Celery Seed Extract?

This is a multi-layered question, and the answer depends on your specific product format and the member states you are targeting. Here is a framework overview - consult qualified regulatory counsel for market-specific advice.

Allergen declaration (mandatory): Celery (Apium graveolens) is listed as one of the 14 major food allergens under Annex II of EU Food Information to Consumers Regulation (EU FIC 1169/2011). Any food supplement sold in the EU that contains celery seed extract must declare celery as an allergen - in the ingredients list with typographic emphasis (bold, underline, or contrasting color) and in any allergen summary statement. This is non-negotiable and applies regardless of the concentration of celery seed extract in the finished product.

Novel food status: Celery seed (Apium graveolens L., seed) has a documented history of use as a food and food supplement ingredient in the EU prior to May 1997, which means it is not subject to Novel Food authorization under EU Regulation 2015/2283 when used in traditional forms and at traditional use levels. However, if you are using a highly concentrated extract or a novel delivery format, confirm the novel food status with your EU regulatory counsel.

Health claims: Under EU Regulation 1924/2006, health claims on food supplements must be authorized and listed on the EU Register of authorized claims. There are currently no authorized EU health claims for celery seed extract or phthalides. Structure/function claims that imply disease prevention or treatment are not permitted on food supplement labels in the EU. Claims must be limited to general well-being statements or authorized nutrient function claims.

Organic labeling: Products containing ≥95% organic ingredients (by weight of agricultural ingredients) may carry the EU organic logo and "organic" designation under EU Regulation 848/2018. The EU organic logo placement and associated text requirements are specific - confirm with your organic certifier.

Q7: What is the recommended dosage of Organic Celery Seed Extract in supplement formulations?

Dosage recommendations for celery seed extract in supplement formulations are based on traditional use data, preclinical research, and the limited available human study literature. There is no established pharmacopoeial monograph dose for standardized celery seed extract, so the following represents a synthesis of available evidence and commercial practice.

For cardiovascular wellness and blood pressure support positioning:

• Typical range: 150–500 mg per serving of standardized extract (≥85% phthalides, ≥1.0% 3nB)
• Once or twice daily dosing is the most common commercial approach
• The traditional Ayurvedic use of celery seed (ajmoda) as a diuretic and antihypertensive involved doses of 1–3 g of whole seed per day; standardized extract at 85% phthalides represents a significant concentration relative to whole seed

For joint health and uric acid support positioning:

• Typical range: 250–500 mg per serving
• Often combined with tart cherry extract (480–1,000 mg) and/or quercetin (250–500 mg) in combination joint health formulas

For combination formulas:

• 100–250 mg per serving as a supporting ingredient alongside primary actives with stronger clinical substantiation

Important caveat: These dosage ranges are derived from commercial practice and traditional use data, not from large-scale, dose-finding clinical trials. Formulators should review the available published literature and consult with a qualified clinical nutritionist or pharmacognosist when establishing dosage claims, particularly for markets with strict claim substantiation requirements.

Jiuyuan Biotech supplies Organic Celery Seed Extract to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

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