Prunella Vulgaris Extract

Prunella vulgaris extract is a natural plant essence that is extracted, concentrated, and dried from the labiate plant, Prunella vulgaris L. It retains the unique medicinal value of the plant, and its appearance is a brownish to brownish-yellow powder with a slightly bitter taste. The extract is stable and easily soluble in water.

Prunella vulgaris, also known as "self-heal," is a perennial herbaceous plant whose medicinal part is the dried fruiting spike. It's typically harvested in the summer when the spikes are half-withered and then dried in the sun. It's a labiate plant widely distributed around the world, and is particularly common in both northern and southern China.

At Jiuyuan Biotech, our Prunella Vulgaris Extract is produced from aerial parts - primarily the characteristic purple flower spikes - harvested at peak phenological stage from cultivated material in Shaanxi and Henan provinces. Every batch is standardized by HPLC and ships with a full Certificate of Analysis.

• Natural and Safe: Extracted from a natural herb with no synthetic additives, it has a high level of safety.
• Multiple Benefits: One extract provides multiple benefits, giving it a wide range of applications and high added value.
• Standardized Production: Modern extraction and drying technologies ensure a stable content of active ingredients and controllable quality for every batch of prunella vulgaris extract.
• Strong Market Foundation: Prunella vulgaris has a long history in traditional Chinese medicine and folk applications, giving it high consumer awareness and a good market foundation.

Phenolic Acids & Polyphenols (Primary Bioactive Class)

• Rosmarinic Acid - The dominant and most commercially significant marker in P. vulgaris extract. A caffeic acid ester with well-documented antioxidant, anti-inflammatory, and antimicrobial properties. Inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide production in macrophage models - a mechanistically specific anti-inflammatory action. Also listed in the EU CosIng database as an antioxidant cosmetic ingredient. Rosmarinic acid is the primary HPLC standardization target for supplement and cosmetic grades.
• Caffeic Acid - A hydroxycinnamic acid precursor to rosmarinic acid; present at lower concentrations but contributes to the extract's overall radical-scavenging capacity.
• Chlorogenic Acid - A secondary polyphenolic marker; useful as a supplementary HPLC reference point for batch consistency verification.
• Triterpenoids
• Ursolic Acid - A pentacyclic triterpene present at significant concentrations in P. vulgaris aerial parts, particularly in the leaf fraction. Documented anti-inflammatory, hepatoprotective, and anti-tumor activities in preclinical research. Ursolic acid is the primary marker for our dedicated triterpene-enriched grade, standardized to ≥ 25% by HPLC.
• Oleanolic Acid - A structural isomer of ursolic acid; co-occurs in the triterpene fraction and contributes to the hepatoprotective activity profile.
• Betulinic Acid - Present in trace amounts; a triterpenoid with documented antiviral and pro-apoptotic properties in preclinical models.

Flavonoids

• Rutin - A quercetin glycoside; contributes antioxidant capacity and capillary-protective activity.
• Hyperoside, Isoquercitrin - Quercetin glycosides present in the aerial parts; support the extract's overall flavonoid profile.
• Luteolin, Apigenin - Free aglycone flavones; documented anti-inflammatory and antioxidant activity.

Polysaccharides (Antiviral Fraction)

• Prunellin - A sulfated polysaccharide isolated from aqueous extracts of P. vulgaris; documented as an anti-HIV component in peer-reviewed literature, acting by inhibiting viral entry into host cells.
• Anti-HSV Polysaccharides - Distinct polysaccharide fractions from P. vulgaris have demonstrated inhibitory activity against Herpes Simplex Virus (HSV) in preclinical models, with a proposed mechanism involving interference with viral attachment to host cell receptors.

The various active ingredients in prunella vulgaris extract work synergistically, giving it significant pharmacological activity.

• Liver-clearing and Vision-improving, Blood Pressure-lowering: Components like oleanolic acid and quercetin in the extract have a vasodilatory and blood pressure-lowering effect. They also protect the liver and can relieve symptoms such as red, swollen eyes and dizziness caused by excessive liver fire.
• Antibacterial and Anti-inflammatory: Flavonoids and phenolic acids can inhibit various pathogenic microorganisms, such as Staphylococcus aureus, Streptococcus, and E. coli, and also have an inhibitory effect on many inflammatory reactions.
• Antiviral: Studies have shown that prunella vulgaris extract has an inhibitory effect on certain viruses, which helps fight viral infections.
• Antioxidant: The polyphenols in the extract have excellent antioxidant activity, which can scavenge free radicals and delay cellular aging.
• Antitumor: Triterpenoids like oleanolic acid have been found in studies to have the potential to inhibit the proliferation of tumor cells and induce their apoptosis.

Prunella vulgaris extract is typically made by using water or ethanol as a solvent for extraction, followed by concentration, filtration, and spray drying.

• Raw Material Selection: High-quality, dried prunella vulgaris is selected.
• Extraction: After grinding the raw materials, they are extracted with purified water or an ethanol-water solution at a specific temperature.
• Filtration: Plant residues are removed to get a clear extract solution.
• Concentration: The majority of the solvent is removed through vacuum concentration, resulting in a concentrated liquid.
• Drying: The concentrated liquid is spray-dried to create the prunella vulgaris extract powder.
• Grinding and Packaging: The powder is sieved and ground to the required mesh size, then packaged and prepared for distribution.

Market context: The post-pandemic sustained interest in antiviral and immune-support botanicals has created durable demand for ingredients with credible antiviral mechanisms - not just general "immune support" positioning. P. vulgaris extract, with its documented polysaccharide-mediated antiviral activity and rosmarinic acid-driven anti-inflammatory profile, occupies a differentiated position in this space that generic echinacea or elderberry formulas cannot replicate.

In-House Laboratory Capabilities:

• HPLC (rosmarinic acid, ursolic acid, oleanolic acid quantification)
• UV-Vis spectrophotometry (total polyphenol content by Folin-Ciocalteu; total flavonoid content)
• DPPH / ABTS radical scavenging assay (antioxidant capacity)
• ICP-MS (heavy metals: As, Pb, Cd, Hg)
• GC-MS (solvent residues per ICH Q3C)
• Microbiological panel (E. coli, Salmonella, S. aureus, TPC, yeast & mold)
• TLC (botanical identity verification against reference standard)
• Karl Fischer titration (moisture)

Traceability:

Each batch carries a unique lot number traceable to raw material harvest records, including GPS-tagged field location, harvest date, and incoming inspection data. This chain-of-custody documentation is available to qualified buyers upon request.

Third-Party Verification:

Split samples from every commercial lot are retained for 24 months. Clients may specify preferred third-party laboratories (SGS, Eurofins, Intertek, or equivalent) for pre-shipment verification - a service we actively support.

At JIUYUAN BIOTECH, product quality is our top priority. We achieve this through a comprehensive and robust quality control system that meticulously manages every stage of production with scientific rigor. By strictly adhering to operational protocols, we ensure the traceability of every batch of our products. Shaanxi jiuyuan Bio currently holds numerous domestic and international industry certifications and qualifications, including cGMP Dynamic Drug Production Management StandardCertification, EU/USDAORGANIC Certification, SC Food Production License, IS0900 Quality Management System Certifica-tion, IS022000 Food Safety Management System Certification, FSSC22000 Global Standard for Food Safety, Health Food Raw Material Production License, HACCP(Hazard Analysis and Critical Control Points)System Certification, Kosher Certification, Halal Certification, and FDA registration. Our operations in production, research and development, and sales consistently meet the demanding standards. With advanced production facilities, a state-of-the-art testing and control center, and our complete quality control system, we consistently ensure the safety and stability of our products and services.

Founded in 2012, Shaanxi Jiuyuan Biotechnology Co., Ltd. is based at the northern foot of the Qinling Mountains in Huyi District, Xi'an City. We are a dynamic high-tech enterprise that integrates the research and development, production, and sales of plant extracts and fruit and vegetable powders. For many years, our company has been committed to delivering high-quality products and services to customers in the health food, food, and cosmetic industries, with a strong drive to lead China's plant extract industry.

We are equipped with state-of-the-art testing equipment, such as HPLC and UV spectrometers, enabling precise analysis of active ingredient content and purity. Our professional testing team provides detailed product analysis reports, ensuring product quality and safety.

We have established long-term, stable partnerships with local farmers to ensure a consistent supply of raw materials. Through contract farming and procurement, we guarantee the quality and quantity of raw materials, providing reliable material assurance to our clients.

We possess comprehensive production and warehousing facilities to meet large-volume client demands. Our factory is equipped with advanced production equipment and automated production lines, enabling efficient production of high-quality products. Our warehousing facilities provide optimal storage conditions, ensuring product quality and stability during storage.

If you have any questions or need free samples, please send an email to: info@jiuybiotech.com

Express Under 100kg, 3-5Days Door-to-door service easy to pick up the goods	By Sea Over300kg, Around 30 Days Port-to-port service professional clearance broker needed	By Air 100kg-1000kg, 5-7Days Airport-to-airport service professional clearance broker needed

Storage: Keep in a cool, dry, and clean place. Protect from moisture and direct light.

Bulk Package: 25kg/drum.

Lead Time: 7 days after your order.

Shelf Life: 2 years.

Remark: Customized specifications can also be achieved.

Q1: What is rosmarinic acid, and why is it the primary standardization marker for Prunella Vulgaris Extract?

Rosmarinic acid is a caffeic acid ester - a polyphenolic compound found across the Lamiaceae family, of which P. vulgaris is a member. It is the most abundant and pharmacologically well-characterized bioactive in P. vulgaris aerial parts, with documented antioxidant, anti-inflammatory, and antimicrobial activities. Specifically, it inhibits LPS-induced prostaglandin E2 and nitric oxide synthesis in macrophage models - a mechanistically specific anti-inflammatory action that supports its use in both supplement and cosmetic formulations. It is also analytically tractable by HPLC with high precision, making it the most reliable batch-to-batch consistency marker available for this extract.

Q2: What is the evidence for Prunella Vulgaris Extract's antiviral activity?

The antiviral activity of P. vulgaris is primarily attributed to its sulfated polysaccharide fraction, particularly a compound designated prunellin, which was identified as an anti-HIV component from aqueous extracts in peer-reviewed research. Separately, distinct polysaccharide fractions from P. vulgaris have demonstrated inhibitory activity against Herpes Simplex Virus (HSV) types 1 and 2 in preclinical models, with a proposed mechanism involving interference with viral attachment to host cell surface receptors. It is important to note that this evidence is preclinical - finished product antiviral claims require independent regulatory review and, in most jurisdictions, clinical substantiation before they can be made on product labels.

Q3: Is Prunella Vulgaris Extract approved for use in cosmetic products in the EU?

Yes. Prunella vulgaris extract is listed in the EU CosIng (Cosmetic Ingredients) database with the primary listed function of antioxidant. It is used in moisturizers, serums, essences, and ampoules - product categories where antioxidant and anti-inflammatory claims are both commercially relevant and well-supported by the ingredient's rosmarinic acid content. No restriction or concentration limit is currently specified in Annex III of the EU Cosmetics Regulation for this ingredient, but formulators should conduct standard safety assessment procedures (CPSR) as required for all cosmetic ingredients.

Q4: How does Prunella Vulgaris Extract differ from Rosemary Extract, given both contain rosmarinic acid?

The overlap in rosmarinic acid content is real - both P. vulgaris and rosemary (Rosmarinus officinalis) are Lamiaceae family members with meaningful rosmarinic acid concentrations. However, the two extracts differ in three important ways. First, P. vulgaris extract contains ursolic acid and oleanolic acid as significant triterpene contributors, which are present at much lower levels in rosemary. Second, P. vulgaris uniquely contains antiviral polysaccharides (prunellin and related fractions) with no equivalent in rosemary. Third, rosemary extract is better known for carnosic acid and carnosol - diterpene antioxidants absent in P. vulgaris. The choice between them should be driven by the specific bioactivity profile your formulation requires, not by rosmarinic acid content alone.

Q5: What phytochemical research supports the anti-inflammatory activity of this extract?

A comprehensive review of the genus Prunella published in the Journal of Ethnopharmacology documented multiple anti-inflammatory mechanisms, including inhibition of NF-κB signaling, suppression of COX-2 expression, and reduction of pro-inflammatory cytokine production. Phytochemical characterization studies have confirmed that rosmarinic acid, luteolin, and apigenin - all present in P. vulgaris aerial parts - independently contribute to these anti-inflammatory effects through complementary mechanisms. This multi-target anti-inflammatory profile is characteristic of the extract's value as a whole-plant ingredient rather than an isolated compound.

Q6: What storage and handling conditions are required to maintain extract potency?

Store in a sealed container in a cool (< 25°C), dry (< 60% RH), dark environment. Rosmarinic acid is relatively stable under standard storage conditions but degrades under prolonged UV exposure and in alkaline aqueous environments. During manufacturing, avoid sustained temperatures above 60°C and alkaline pH conditions. The powder is not classified as hazardous under standard occupational health guidelines, but standard dust-handling precautions (mask, gloves) apply when working with fine botanical powders. Opened packaging should be resealed under nitrogen or inert gas where possible.

Q7: Can you supply an organic-certified grade?

Yes. An organic-certified grade produced from raw material cultivated under USDA NOP and EU organic standards is available on request. The organic grade carries a longer lead time (typically 3–4 weeks for initial orders) and is priced at a premium reflecting the certified supply chain. USDA Organic and EU Organic certificates are available upon request for qualified buyers.

Q8: What documentation is available to support EU or US regulatory submissions?

For EU supplement and cosmetic submissions, we can provide: Certificate of Analysis (per lot), botanical identity documentation (macroscopic + TLC), heavy metals and pesticide residue test reports, solvent residue reports (ICH Q3C), microbiological test reports, non-GMO declaration, and allergen statement. For US DSHEA submissions, the same documentation package applies, supplemented by a country of origin certificate and, where required, a Prop 65 compliance statement for California-destined products. Our technical team can also provide a product specification sheet formatted to common retailer qualification templates (e.g., Amazon, iHerb, Whole Foods supplier requirements).

Jiuyuan Biotech supplies Prunella Vulgaris Extract to food manufacturers, supplement brands, and contract formulators across North America, Europe, and the Asia-Pacific region. Our technical team - not a generic sales inbox - handles every inquiry.

Email: info@jiuyuanbio.com

Website: www.jiuyuanbio.com

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